Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 404010..404611 Replicon chromosome
Accession NZ_CP017085
Organism Proteus mirabilis strain T18

Toxin (Protein)


Gene name doc Uniprot ID A0A1Z1SQZ4
Locus tag BG029_RS02000 Protein ID WP_036895893.1
Coordinates 404010..404393 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag BG029_RS02005 Protein ID WP_004246496.1
Coordinates 404390..404611 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG029_RS01975 399074..400561 - 1488 WP_087726303.1 PLP-dependent aminotransferase family protein -
BG029_RS01980 400690..401148 + 459 Protein_367 GNAT family N-acetyltransferase -
BG029_RS01985 401244..401981 - 738 WP_004249950.1 sel1 repeat family protein -
BG029_RS01990 402090..402989 + 900 WP_017826985.1 N-acetylmuramic acid 6-phosphate etherase -
BG029_RS01995 403289..403603 - 315 WP_004246498.1 helix-turn-helix domain-containing protein -
BG029_RS02000 404010..404393 - 384 WP_036895893.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
BG029_RS02005 404390..404611 - 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BG029_RS02010 404892..405755 - 864 WP_004249947.1 YicC family protein -
BG029_RS02015 405882..406598 + 717 WP_004249760.1 ribonuclease PH -
BG029_RS02020 406680..407324 + 645 WP_004246493.1 orotate phosphoribosyltransferase -
BG029_RS02025 407643..408248 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -
BG029_RS02030 408368..408826 - 459 WP_004246490.1 dUTP diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14518.52 Da        Isoelectric Point: 8.4945

>T65884 WP_036895893.1 NZ_CP017085:c404393-404010 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGRIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNTLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T65884 NZ_CP017085:c404393-404010 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCGCATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACCGACAATACGCTGGAAAACTTAACAGTGGAAGCGGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT65884 WP_004246496.1 NZ_CP017085:c404611-404390 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT65884 NZ_CP017085:c404611-404390 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATTTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCAGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCGCTGACAAATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z1SQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References