Detailed information of TA system TA065881

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 1329..2028
• Replicon: chromosome
• Accession: NZ_CP017085
• Organism: Proteus mirabilis strain T18

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BG029_RS00010
• Protein ID: WP_017628658.1
• Coordinates: 1329..1715 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: BG029_RS00015
• Protein ID: WP_004246828.1
• Coordinates: 1708..2028 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BG029_RS00010	1329..1715	+	387	WP_017628658.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BG029_RS00015	1708..2028	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
BG029_RS00020	2077..2511	-	435	WP_004246827.1	hypothetical protein	-
BG029_RS00025	2504..3388	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
BG029_RS00030	3603..4889	-	1287	WP_063073863.1	DUF3748 domain-containing protein	-
BG029_RS00035	5026..5643	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
BG029_RS00040	5944..6567	+	624	WP_004246821.1	guanylate kinase	-
BG029_RS00045	6622..6897	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14322.65 Da
• Isoelectric Point: 10.0826

>T65881 WP_017628658.1 NZ_CP017085:1329-1715 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVRYD

Nucleotide

• Length: 387 bp

>T65881 NZ_CP017085:1329-1715 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATCGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAGATATGACTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT65881 WP_004246828.1 NZ_CP017085:1708-2028 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT65881 NZ_CP017085:1708-2028 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAGGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTGCATTTAATAGATAAAAAAATATTATTCATCTA
G

Structures

Antitoxin

• AlphaFold DB: B4EZ97