Detailed information of TA system TA065876

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 1511053..1511752
• Replicon: chromosome
• Accession: NZ_CP017082
• Organism: Proteus mirabilis strain T21

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BG257_RS07265
• Protein ID: WP_017628658.1
• Coordinates: 1511366..1511752 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: BG257_RS07260
• Protein ID: WP_004246828.1
• Coordinates: 1511053..1511373 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BG257_RS07230	1506184..1506459	-	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-
BG257_RS07235	1506514..1507137	-	624	WP_004246821.1	guanylate kinase	-
BG257_RS07240	1507438..1508055	-	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
BG257_RS07245	1508192..1509478	+	1287	WP_063073863.1	DUF3748 domain-containing protein	-
BG257_RS07250	1509693..1510577	+	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
BG257_RS07255	1510570..1511004	+	435	WP_004246827.1	hypothetical protein	-
BG257_RS07260	1511053..1511373	-	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
BG257_RS07265	1511366..1511752	-	387	WP_017628658.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BG257_RS07270	1511914..1513986	-	2073	WP_017628659.1	glycine--tRNA ligase subunit beta	-
BG257_RS07275	1513996..1514901	-	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
BG257_RS07280	1515152..1515733	+	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14322.65 Da
• Isoelectric Point: 10.0826

>T65876 WP_017628658.1 NZ_CP017082:c1511752-1511366 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVRYD

Nucleotide

• Length: 387 bp

>T65876 NZ_CP017082:c1511752-1511366 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATCGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAGATATGACTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT65876 WP_004246828.1 NZ_CP017082:c1511373-1511053 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT65876 NZ_CP017082:c1511373-1511053 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAGGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTGCATTTAATAGATAAAAAAATATTATTCATCTA
G

Structures

Antitoxin

• AlphaFold DB: B4EZ97