Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1347568..1348369 Replicon chromosome
Accession NZ_CP017082
Organism Proteus mirabilis strain T21

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0XS49
Locus tag BG257_RS06510 Protein ID WP_001094437.1
Coordinates 1347992..1348369 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0XTQ1
Locus tag BG257_RS06505 Protein ID WP_001390338.1
Coordinates 1347568..1347945 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG257_RS06475 1344683..1344841 + 159 WP_001323397.1 DUF905 family protein -
BG257_RS06485 1344996..1345814 + 819 WP_001535681.1 DUF945 domain-containing protein -
BG257_RS20625 1346156..1346629 + 474 WP_000855064.1 antirestriction protein -
BG257_RS06495 1346645..1347121 + 477 WP_001535682.1 RadC family protein -
BG257_RS06500 1347184..1347405 + 222 WP_000692345.1 DUF987 domain-containing protein -
BG257_RS06505 1347568..1347945 + 378 WP_001390338.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BG257_RS06510 1347992..1348369 + 378 WP_001094437.1 TA system toxin CbtA family protein Toxin
BG257_RS20630 1348366..1348854 + 489 WP_000761716.1 hypothetical protein -
BG257_RS06520 1348874..1349071 + 198 WP_000772032.1 DUF957 domain-containing protein -
BG257_RS06525 1349156..1350001 + 846 WP_001274561.1 DUF4942 domain-containing protein -
BG257_RS06530 1350544..1351578 + 1035 WP_017628609.1 virulence RhuM family protein -
BG257_RS06535 1351703..1351855 - 153 Protein_1227 transposase -
BG257_RS06540 1352626..1352946 + 321 WP_004246668.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13986.90 Da        Isoelectric Point: 7.3223

>T65875 WP_001094437.1 NZ_CP017082:1347992-1348369 [Proteus mirabilis]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T65875 NZ_CP017082:1347992-1348369 [Proteus mirabilis]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCATCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13745.44 Da        Isoelectric Point: 5.0463

>AT65875 WP_001390338.1 NZ_CP017082:1347568-1347945 [Proteus mirabilis]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV

Download         Length: 378 bp

>AT65875 NZ_CP017082:1347568-1347945 [Proteus mirabilis]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGCTTATCTGGCTGTTTATCCGACACCGGCAGAGCCCGCAATCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XS49

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XTQ1

References