Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1108467..1109068 Replicon chromosome
Accession NZ_CP017082
Organism Proteus mirabilis strain T21

Toxin (Protein)


Gene name doc Uniprot ID A0A1Z1SQZ4
Locus tag BG257_RS05275 Protein ID WP_036895893.1
Coordinates 1108685..1109068 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag BG257_RS05270 Protein ID WP_004246496.1
Coordinates 1108467..1108688 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG257_RS05245 1104252..1104710 + 459 WP_004246490.1 dUTP diphosphatase -
BG257_RS05250 1104830..1105435 + 606 WP_004246491.1 nucleoid occlusion factor SlmA -
BG257_RS05255 1105754..1106398 - 645 WP_004246493.1 orotate phosphoribosyltransferase -
BG257_RS05260 1106480..1107196 - 717 WP_004249760.1 ribonuclease PH -
BG257_RS05265 1107323..1108186 + 864 WP_004249947.1 YicC family protein -
BG257_RS05270 1108467..1108688 + 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BG257_RS05275 1108685..1109068 + 384 WP_036895893.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
BG257_RS05280 1109475..1109789 + 315 WP_004246498.1 helix-turn-helix domain-containing protein -
BG257_RS05285 1110089..1110988 - 900 WP_017826985.1 N-acetylmuramic acid 6-phosphate etherase -
BG257_RS05290 1111097..1111834 + 738 WP_004249950.1 sel1 repeat family protein -
BG257_RS05295 1111930..1112388 - 459 Protein_1007 GNAT family N-acetyltransferase -
BG257_RS05300 1112517..1114004 + 1488 WP_087726303.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14518.52 Da        Isoelectric Point: 8.4945

>T65873 WP_036895893.1 NZ_CP017082:1108685-1109068 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGRIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNTLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T65873 NZ_CP017082:1108685-1109068 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCGCATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACCGACAATACGCTGGAAAACTTAACAGTGGAAGCGGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT65873 WP_004246496.1 NZ_CP017082:1108467-1108688 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT65873 NZ_CP017082:1108467-1108688 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATTTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCAGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCGCTGACAAATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z1SQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References