Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 812485..813098 Replicon plasmid pSA2
Accession NZ_CP017077
Organism Novosphingobium resinovorum strain SA1

Toxin (Protein)


Gene name PumA Uniprot ID A0A1D8AFC7
Locus tag BES08_RS28820 Protein ID WP_069710098.1
Coordinates 812769..813098 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A1D8AFB2
Locus tag BES08_RS28815 Protein ID WP_069710097.1
Coordinates 812485..812772 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BES08_RS28795 807610..809256 + 1647 WP_069710094.1 IS66 family transposase -
BES08_RS28800 810466..810690 - 225 WP_069710095.1 hypothetical protein -
BES08_RS28805 811092..811517 + 426 WP_069710096.1 hypothetical protein -
BES08_RS28810 811703..812023 - 321 WP_008832418.1 DUF736 family protein -
BES08_RS28815 812485..812772 - 288 WP_069710097.1 putative addiction module antidote protein Antitoxin
BES08_RS28820 812769..813098 - 330 WP_069710098.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BES08_RS28825 813343..815172 - 1830 WP_008831236.1 ParB/RepB/Spo0J family partition protein -
BES08_RS28830 815264..815674 - 411 WP_008831237.1 DUF2958 domain-containing protein -
BES08_RS28835 815671..816690 - 1020 WP_008831238.1 DUF1738 domain-containing protein -
BES08_RS28840 817190..817585 + 396 WP_069710099.1 thermonuclease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB 1..960805 960805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-94)

Antitoxin

Uncharacterized protein HI1420

(4-91)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12225.02 Da        Isoelectric Point: 11.0026

>T65869 WP_069710098.1 NZ_CP017077:c813098-812769 [Novosphingobium resinovorum]
MEVTQTAVFAQWFHRLRDPKAQSRIAQRIARIEICLMGDVKSVGDGVSEARIDYGLGYRLYFTRRGDELVILLVGGDKSS
QQRDIARARQLAAQLRGAPESARPRRAAP

Download         Length: 330 bp

>T65869 NZ_CP017077:c813098-812769 [Novosphingobium resinovorum]
ATGGAGGTAACGCAAACTGCGGTCTTCGCGCAGTGGTTTCACCGTCTACGCGACCCAAAGGCGCAGTCCAGGATCGCGCA
GCGGATCGCTCGCATCGAGATCTGCCTGATGGGCGACGTGAAATCGGTGGGAGACGGCGTATCCGAAGCCCGCATCGATT
ATGGGCTGGGTTACCGGCTCTATTTCACGCGGCGCGGAGATGAGCTGGTTATCCTGCTGGTCGGCGGCGACAAGTCCTCC
CAGCAGCGGGATATCGCCAGAGCAAGGCAACTCGCGGCTCAGCTTCGAGGCGCACCGGAATCGGCCAGGCCAAGGAGGGC
AGCGCCATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10256.91 Da        Isoelectric Point: 6.4632

>AT65869 WP_069710097.1 NZ_CP017077:c812772-812485 [Novosphingobium resinovorum]
MTIELTRFDAATYLTQPEDQAQLLAAAVESGDPHIVAKAIGIVARAHGMTELARETGMKRQQLYRALGPDGNPTLETMLK
VLPALGLRMRIEAAA

Download         Length: 288 bp

>AT65869 NZ_CP017077:c812772-812485 [Novosphingobium resinovorum]
ATGACTATCGAACTTACCCGCTTCGATGCGGCCACGTATCTTACACAGCCGGAAGATCAGGCGCAGCTCCTCGCAGCGGC
GGTGGAGTCCGGCGATCCGCACATTGTCGCCAAGGCGATCGGCATTGTCGCGCGCGCCCACGGCATGACCGAGCTCGCCC
GCGAAACCGGAATGAAGCGCCAGCAACTCTACCGGGCGCTTGGCCCCGATGGCAATCCGACCCTCGAAACCATGCTCAAG
GTCCTGCCTGCGCTCGGCCTCAGGATGCGGATCGAGGCCGCTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D8AFC7

Antitoxin

Source ID Structure
AlphaFold DB A0A1D8AFB2

References