Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 153371..154007 Replicon chromosome
Accession NZ_CP017071
Organism Geobacillus thermoleovorans strain FJAT-2391

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag BGM21_RS00860 Protein ID WP_003253417.1
Coordinates 153657..154007 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID G8N2B5
Locus tag BGM21_RS00855 Protein ID WP_011229742.1
Coordinates 153371..153652 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BGM21_RS00835 149628..150245 - 618 WP_014194682.1 rhomboid family intramembrane serine protease -
BGM21_RS00840 150359..150748 + 390 WP_011229738.1 holo-ACP synthase -
BGM21_RS00845 150828..151841 + 1014 WP_014194683.1 outer membrane lipoprotein carrier protein LolA -
BGM21_RS00850 152090..153244 + 1155 WP_011229741.1 alanine racemase -
BGM21_RS00855 153371..153652 + 282 WP_011229742.1 hypothetical protein Antitoxin
BGM21_RS00860 153657..154007 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
BGM21_RS00865 154273..156438 + 2166 WP_069303970.1 RNA-binding transcriptional accessory protein -
BGM21_RS18400 156457..156570 - 114 WP_013144046.1 cortex morphogenetic protein CmpA -
BGM21_RS00870 156660..157109 + 450 WP_011229744.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T65859 WP_003253417.1 NZ_CP017071:153657-154007 [Geobacillus thermoleovorans]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T65859 NZ_CP017071:153657-154007 [Geobacillus thermoleovorans]
TTGATTGTCAAACGTGGCGACGTGTATTTTGCGGACCTTTCCCCGGTTGTTGGCTCGGAGCAGGGCGGCGTGCGCCCCGT
GTTGGTGATCCAAAACGATATCGGCAATCGTTTTAGCCCGACGGTGATTGTCGCGGCGATTACGGCGCAAATCCAAAAAG
CGAAGCTGCCGACGCATGTCGAGATTGACGCGAAACGCTACGGGTTTGAACGCGATTCGGTCATTTTGCTTGAGCAAATT
CGCACGATCGACAAGCAACGGCTGACCGATAAAATCACTCATTTGGACGATGAAATGATGGATAAAGTCGATGAGGCGCT
GCAAATTAGCTTAGGGCTGATCGACTTTTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10639.14 Da        Isoelectric Point: 7.2027

>AT65859 WP_011229742.1 NZ_CP017071:153371-153652 [Geobacillus thermoleovorans]
VSESGATAEIVVRLPQSLLTELDVLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFHAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT65859 NZ_CP017071:153371-153652 [Geobacillus thermoleovorans]
GTGTCGGAATCTGGCGCAACAGCGGAAATCGTCGTTCGTTTGCCGCAGTCGCTGCTGACAGAACTGGACGTGCTCGTAAA
GCAGGAAAACGGCAACCGCAATGAACTCATTTATCAAGCGACGAAAATGTACATTCGCGAGCGGAAGAAACGGCAAATTC
GCGAGGCGATGAGACGAGGCTACATGGAAATGGCGAAAATCAATTTATCTATCGCTTCTGAAGCGTTTCATGCTGAATAC
GAGGCCGACCACACCGTTGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9ETW5

References