Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 972510..973027 Replicon chromosome
Accession NZ_CP017069
Organism Staphylococcus lugdunensis strain K93G

Toxin (Protein)


Gene name mazF Uniprot ID A0A853V3R6
Locus tag BFP67_RS04570 Protein ID WP_002461192.1
Coordinates 972677..973027 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A853V233
Locus tag BFP67_RS04565 Protein ID WP_002461193.1
Coordinates 972510..972680 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFP67_RS04540 968335..968817 + 483 WP_002492078.1 PH domain-containing protein -
BFP67_RS04545 968810..970324 + 1515 WP_002492082.1 PH domain-containing protein -
BFP67_RS04550 970311..970823 + 513 WP_002461197.1 PH domain-containing protein -
BFP67_RS04555 970835..971227 + 393 WP_002461196.1 holo-ACP synthase -
BFP67_RS04560 971275..972423 + 1149 WP_002492086.1 alanine racemase -
BFP67_RS04565 972510..972680 + 171 WP_002461193.1 hypothetical protein Antitoxin
BFP67_RS04570 972677..973027 + 351 WP_002461192.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BFP67_RS04575 973460..974461 + 1002 WP_002461191.1 PP2C family protein-serine/threonine phosphatase -
BFP67_RS04580 974552..974878 + 327 WP_002461190.1 anti-sigma factor antagonist -
BFP67_RS04585 974880..975359 + 480 WP_037540680.1 anti-sigma B factor RsbW -
BFP67_RS04590 975334..976104 + 771 WP_002461188.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13079.20 Da        Isoelectric Point: 9.9784

>T65856 WP_002461192.1 NZ_CP017069:972677-973027 [Staphylococcus lugdunensis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIGKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDHALDISLGLHNYH

Download         Length: 351 bp

>T65856 NZ_CP017069:972677-973027 [Staphylococcus lugdunensis]
ATGATTAGACGCGGCGATGTATATTTAGCTGATTTATCACCGGTACAAGGGTCTGAACAAGGGGGAGTAAGACCAGTTGT
TATCATTCAAAATGACACCGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCAATTACTGGAAGGATTAATAAAGCGA
AAATACCCACTCATGTGGAAATAGGTAAAAAGAAATATAAGTTAGATAAAGATTCTGTTATTCTGTTAGAGCAAATACGA
ACATTAGATAAAAAAAGATTAAAAGAAAAACTTACTTATCTCTCTGAGGATAAAATGAAAGAAGTAGATCATGCCCTAGA
CATTAGTCTAGGTTTACATAACTATCATTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.92 Da        Isoelectric Point: 4.0115

>AT65856 WP_002461193.1 NZ_CP017069:972510-972680 [Staphylococcus lugdunensis]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNHQSE

Download         Length: 171 bp

>AT65856 NZ_CP017069:972510-972680 [Staphylococcus lugdunensis]
ATGCTAACTTTTAATCAAAATCGTAGTCATAGTCTAGAACAGTCATTAAAAGAAGGGTATGCTCAGATGGCAGACCTTAA
TCTCTCCCTAGCAACAGAGGCTTTTCCAATTGAATGTGAAGCTTGTGATTGCAATGAAACTTATCTAACTTCCAATCATC
AGAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3R6

Antitoxin

Source ID Structure
AlphaFold DB A0A853V233

References