Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2120211..2120862 Replicon chromosome
Accession NZ_CP017054
Organism Providencia stuartii strain BE2467

Toxin (Protein)


Gene name Hha Uniprot ID K8W3H1
Locus tag BGK56_RS10010 Protein ID WP_004927064.1
Coordinates 2120659..2120862 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B2Q721
Locus tag BGK56_RS10005 Protein ID WP_004927067.1
Coordinates 2120211..2120579 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BGK56_RS09975 2115351..2116112 - 762 WP_004927092.1 DNA polymerase III subunit epsilon -
BGK56_RS09980 2116167..2116637 + 471 WP_014656762.1 ribonuclease HI -
BGK56_RS09985 2116716..2117441 - 726 WP_053110025.1 methyltransferase domain-containing protein -
BGK56_RS09990 2117475..2118230 + 756 WP_004927081.1 hydroxyacylglutathione hydrolase -
BGK56_RS09995 2118309..2119643 + 1335 WP_072502514.1 murein transglycosylase D -
BGK56_RS10005 2120211..2120579 + 369 WP_004927067.1 Hha toxicity modulator TomB Antitoxin
BGK56_RS10010 2120659..2120862 + 204 WP_004927064.1 hemolysin expression modulator Hha Toxin
BGK56_RS10020 2121468..2121926 - 459 WP_004927062.1 YbaY family lipoprotein -
BGK56_RS10025 2122249..2123115 + 867 WP_072502515.1 acyl-CoA thioesterase II -
BGK56_RS10030 2123352..2124635 - 1284 WP_014656764.1 ammonium transporter AmtB -
BGK56_RS10035 2124646..2124984 - 339 WP_004927053.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8075.37 Da        Isoelectric Point: 6.9770

>T65844 WP_004927064.1 NZ_CP017054:2120659-2120862 [Providencia stuartii]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSEDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T65844 NZ_CP017054:2120659-2120862 [Providencia stuartii]
ATGACCAAAACTGATTATCTGATGCGTTTAAGAAAATGCACAACCATCGATACACTTGAGCGTGTTATTGAGAAAAATAA
GTATGAGCTTTCTGAAGATGAGTTAGAATTGTTCTATTCAGCTGCTGACCATCGCCTTGCAGAACTCACTATGAATAAAC
TTTATGACAAAATCCCTGCATCGGTTTGGAAATTTGTTAGGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14149.01 Da        Isoelectric Point: 4.2591

>AT65844 WP_004927067.1 NZ_CP017054:2120211-2120579 [Providencia stuartii]
MDEYSPKNYDISELKYLCNSLNREAMLSLQKTNTHWVNDLSSPQSARLNELIEHIAAFVWQFKIKYPKENLVISLVEEYL
DETYDLFGSPVITLSEIIDWQSMNQNLVSVLDDDLKCPASKT

Download         Length: 369 bp

>AT65844 NZ_CP017054:2120211-2120579 [Providencia stuartii]
ATGGATGAATATTCACCCAAAAATTATGATATATCTGAGTTAAAATACTTGTGTAACAGTTTGAATCGAGAAGCAATGTT
AAGCTTACAGAAAACTAATACACACTGGGTCAATGATTTAAGTTCACCACAAAGTGCTAGACTTAATGAACTCATTGAAC
ATATTGCAGCCTTCGTGTGGCAATTTAAGATAAAATATCCCAAAGAGAATCTCGTTATATCATTAGTTGAAGAGTATCTT
GATGAGACTTATGATTTATTCGGAAGCCCTGTAATAACTCTAAGTGAAATTATTGACTGGCAGAGCATGAATCAAAATCT
AGTTTCCGTACTTGATGATGATTTAAAGTGCCCTGCAAGCAAAACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K8W3H1

Antitoxin

Source ID Structure
AlphaFold DB A0A140NKN2

References