Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 3072226..3073267 | Replicon | chromosome |
| Accession | NZ_CP017052 | ||
| Organism | Burkholderia pseudomallei strain MSHR3763 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | BGI46_RS16265 | Protein ID | WP_004539802.1 |
| Coordinates | 3072692..3073267 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A0E1SLI7 |
| Locus tag | BGI46_RS16260 | Protein ID | WP_004540053.1 |
| Coordinates | 3072226..3072687 (+) | Length | 154 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BGI46_RS16225 | 3067832..3068500 | - | 669 | WP_012730038.1 | restriction endonuclease fold toxin 5 domain-containing protein | - |
| BGI46_RS16235 | 3068785..3069291 | - | 507 | WP_004539924.1 | DUF4123 domain-containing protein | - |
| BGI46_RS16240 | 3069288..3069713 | - | 426 | WP_004539640.1 | PAAR domain-containing protein | - |
| BGI46_RS39615 | 3070111..3070491 | - | 381 | WP_020850431.1 | hypothetical protein | - |
| BGI46_RS16250 | 3070951..3071178 | - | 228 | WP_004540114.1 | hypothetical protein | - |
| BGI46_RS39620 | 3071175..3071573 | - | 399 | WP_133604798.1 | hypothetical protein | - |
| BGI46_RS16260 | 3072226..3072687 | + | 462 | WP_004540053.1 | excisionase family DNA-binding protein | Antitoxin |
| BGI46_RS16265 | 3072692..3073267 | + | 576 | WP_004539802.1 | PIN domain-containing protein | Toxin |
| BGI46_RS16270 | 3073453..3075669 | + | 2217 | WP_004540097.1 | ATP-binding protein | - |
| BGI46_RS16290 | 3076918..3077097 | + | 180 | WP_004191077.1 | hypothetical protein | - |
| BGI46_RS16300 | 3077281..3077553 | + | 273 | WP_004527347.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 22056.35 Da Isoelectric Point: 6.4079
>T65838 WP_004539802.1 NZ_CP017052:3072692-3073267 [Burkholderia pseudomallei]
MSSNFTVVYDACVLYPAPLRDLLMHLAVTDLYRARWTDMIHDEWTRNLLAKRTDLKPEAIQRTRELMDMHVRDAKVENFE
HLIAAIELPDPDDRHVVAAAMHAGAELIVTMNIKDFPRERVGKYNVSAQHPDDFIVDLWDLNKHKVMEAVARHRKSMKNP
PKSVEDYLDTMANQGLVQTVDALRPYAPWAI
MSSNFTVVYDACVLYPAPLRDLLMHLAVTDLYRARWTDMIHDEWTRNLLAKRTDLKPEAIQRTRELMDMHVRDAKVENFE
HLIAAIELPDPDDRHVVAAAMHAGAELIVTMNIKDFPRERVGKYNVSAQHPDDFIVDLWDLNKHKVMEAVARHRKSMKNP
PKSVEDYLDTMANQGLVQTVDALRPYAPWAI
Download Length: 576 bp
>T65838 NZ_CP017052:3072692-3073267 [Burkholderia pseudomallei]
ATGTCGTCGAACTTTACCGTTGTCTACGATGCGTGCGTCCTATATCCGGCTCCGTTGCGCGACTTGTTGATGCATCTCGC
GGTGACGGATCTGTACCGCGCGCGTTGGACCGATATGATTCATGACGAGTGGACAAGGAATTTGCTCGCGAAGCGAACCG
ACCTGAAACCCGAGGCGATCCAGCGCACGCGGGAACTGATGGACATGCATGTTCGCGACGCGAAAGTGGAAAACTTCGAG
CATCTGATTGCGGCGATCGAGTTGCCCGATCCTGATGATCGTCATGTCGTCGCGGCAGCCATGCATGCTGGGGCGGAACT
CATCGTCACGATGAACATCAAGGATTTCCCGAGGGAGCGGGTCGGAAAGTACAACGTGTCGGCTCAACATCCCGACGATT
TCATCGTCGACTTGTGGGACTTGAACAAGCACAAGGTGATGGAGGCGGTCGCGCGACATCGCAAGTCGATGAAGAACCCG
CCGAAGTCAGTGGAAGACTATCTCGACACGATGGCCAATCAGGGACTCGTGCAGACGGTCGATGCGCTGCGGCCGTATGC
GCCTTGGGCTATCTGA
ATGTCGTCGAACTTTACCGTTGTCTACGATGCGTGCGTCCTATATCCGGCTCCGTTGCGCGACTTGTTGATGCATCTCGC
GGTGACGGATCTGTACCGCGCGCGTTGGACCGATATGATTCATGACGAGTGGACAAGGAATTTGCTCGCGAAGCGAACCG
ACCTGAAACCCGAGGCGATCCAGCGCACGCGGGAACTGATGGACATGCATGTTCGCGACGCGAAAGTGGAAAACTTCGAG
CATCTGATTGCGGCGATCGAGTTGCCCGATCCTGATGATCGTCATGTCGTCGCGGCAGCCATGCATGCTGGGGCGGAACT
CATCGTCACGATGAACATCAAGGATTTCCCGAGGGAGCGGGTCGGAAAGTACAACGTGTCGGCTCAACATCCCGACGATT
TCATCGTCGACTTGTGGGACTTGAACAAGCACAAGGTGATGGAGGCGGTCGCGCGACATCGCAAGTCGATGAAGAACCCG
CCGAAGTCAGTGGAAGACTATCTCGACACGATGGCCAATCAGGGACTCGTGCAGACGGTCGATGCGCTGCGGCCGTATGC
GCCTTGGGCTATCTGA
Antitoxin
Download Length: 154 a.a. Molecular weight: 17155.41 Da Isoelectric Point: 5.5474
>AT65838 WP_004540053.1 NZ_CP017052:3072226-3072687 [Burkholderia pseudomallei]
MNTTVTPAALPSEHEAELARESRRNLVTVVNSHAETQQFDFKDEKGETHTVTLPTSALRLLDEILHQIGNGNAVSIIPIH
AELTTQQAADLLNVSRPYLVQLLEQGEIPFRKVNTHRRVMYLDLIQYKNKIDANRLDALAELTAQAQELGMGY
MNTTVTPAALPSEHEAELARESRRNLVTVVNSHAETQQFDFKDEKGETHTVTLPTSALRLLDEILHQIGNGNAVSIIPIH
AELTTQQAADLLNVSRPYLVQLLEQGEIPFRKVNTHRRVMYLDLIQYKNKIDANRLDALAELTAQAQELGMGY
Download Length: 462 bp
>AT65838 NZ_CP017052:3072226-3072687 [Burkholderia pseudomallei]
ATGAACACCACTGTCACTCCTGCGGCCCTCCCGTCCGAACACGAGGCCGAGCTCGCGCGCGAGTCGCGGCGGAATTTGGT
CACGGTCGTGAACAGCCACGCCGAGACTCAGCAGTTTGATTTCAAGGACGAAAAGGGGGAGACGCATACAGTCACGCTTC
CGACCTCGGCGTTAAGGCTGCTAGACGAGATCCTCCATCAGATCGGAAATGGCAACGCGGTGTCGATCATTCCAATCCAT
GCCGAATTGACGACCCAGCAAGCCGCCGACCTTCTGAATGTCTCGCGTCCGTACCTGGTTCAACTTCTTGAGCAGGGAGA
GATCCCATTCCGGAAGGTAAATACGCATCGACGGGTGATGTATCTGGATCTGATTCAGTACAAAAACAAGATCGATGCGA
ACCGTCTCGACGCGCTGGCTGAACTGACGGCTCAGGCGCAGGAACTTGGAATGGGATATTGA
ATGAACACCACTGTCACTCCTGCGGCCCTCCCGTCCGAACACGAGGCCGAGCTCGCGCGCGAGTCGCGGCGGAATTTGGT
CACGGTCGTGAACAGCCACGCCGAGACTCAGCAGTTTGATTTCAAGGACGAAAAGGGGGAGACGCATACAGTCACGCTTC
CGACCTCGGCGTTAAGGCTGCTAGACGAGATCCTCCATCAGATCGGAAATGGCAACGCGGTGTCGATCATTCCAATCCAT
GCCGAATTGACGACCCAGCAAGCCGCCGACCTTCTGAATGTCTCGCGTCCGTACCTGGTTCAACTTCTTGAGCAGGGAGA
GATCCCATTCCGGAAGGTAAATACGCATCGACGGGTGATGTATCTGGATCTGATTCAGTACAAAAACAAGATCGATGCGA
ACCGTCTCGACGCGCTGGCTGAACTGACGGCTCAGGCGCAGGAACTTGGAATGGGATATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|