Detailed information of TA system TA065837

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2121227..2121783
• Replicon: chromosome
• Accession: NZ_CP017052
• Organism: Burkholderia pseudomallei strain MSHR3763

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: BGI46_RS11175
• Protein ID: WP_023594135.1
• Coordinates: 2121493..2121783 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: BGI46_RS11170
• Protein ID: WP_004541313.1
• Coordinates: 2121227..2121505 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BGI46_RS11150	2117128..2118024	-	897	WP_020850700.1	hypothetical protein	-
BGI46_RS11155	2118102..2118359	-	258	WP_004541318.1	hypothetical protein	-
BGI46_RS11160	2118850..2119119	+	270	WP_020850841.1	ribbon-helix-helix protein, CopG family	-
BGI46_RS11165	2119122..2121146	+	2025	WP_196043030.1	relaxase/mobilization nuclease domain-containing protein	-
BGI46_RS11170	2121227..2121505	+	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
BGI46_RS11175	2121493..2121783	+	291	WP_023594135.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BGI46_RS11180	2121780..2122100	+	321	WP_197540451.1	hypothetical protein	-
BGI46_RS39530	2122296..2122544	+	249	WP_004541364.1	hypothetical protein	-
BGI46_RS40690	2122649..2123308	+	660	WP_020850627.1	hypothetical protein	-
BGI46_RS11190	2123350..2125551	-	2202	WP_004541389.1	AAA family ATPase	-
BGI46_RS11195	2125778..2126299	-	522	WP_004541357.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2113649..2130797	17148

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10892.45 Da
• Isoelectric Point: 9.5554

>T65837 WP_023594135.1 NZ_CP017052:2121493-2121783 [Burkholderia pseudomallei]
MPQVIFAPAAIGDMQRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRVDG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T65837 NZ_CP017052:2121493-2121783 [Burkholderia pseudomallei]
ATGCCACAAGTAATCTTTGCGCCGGCGGCGATCGGGGACATGCAACGGCTCCGCGAATTCCTGAGGCCGAAGAATCCCGA
TGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGTCCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGTCTCATAG
AAGATCTGCCTGAACAGTATCGGGAGTGGCTTATCGATTTTGGGGATAGTGGCTATGTGGCTCGGTACCGCGTCGATGGC
GATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAAGCAGGGTACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT65837 WP_004541313.1 NZ_CP017052:2121227-2121505 [Burkholderia pseudomallei]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT65837 NZ_CP017052:2121227-2121505 [Burkholderia pseudomallei]
ATGGTTACGGCAACATCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCCGAGGCGCGCCGGCGTAC
CCCGCACTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGTGAGGAAAAGCGCGAGGCGCTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCACGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCGAGCTGGGGA
ACTGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0