Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1204670..1205244 Replicon chromosome
Accession NZ_CP017019
Organism Moorella thermoacetica strain DSM 103132

Toxin (Protein)


Gene name mazF Uniprot ID A0A5D3I7H5
Locus tag Maut_RS06140 Protein ID WP_069589142.1
Coordinates 1204897..1205244 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1D7X9U1
Locus tag Maut_RS06135 Protein ID WP_053094734.1
Coordinates 1204670..1204903 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Maut_RS06115 1200046..1201647 - 1602 WP_069589132.1 spore germination protein -
Maut_RS06120 1201731..1201985 - 255 WP_011392529.1 DUF3243 domain-containing protein -
Maut_RS06125 1202279..1202965 - 687 WP_011392530.1 manganese catalase family protein -
Maut_RS06130 1203188..1204330 + 1143 WP_187422269.1 YdcF family protein -
Maut_RS15580 1204429..1204569 + 141 WP_155768199.1 hypothetical protein -
Maut_RS06135 1204670..1204903 + 234 WP_053094734.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
Maut_RS06140 1204897..1205244 + 348 WP_069589142.1 endoribonuclease MazF Toxin
Maut_RS06145 1205595..1207124 + 1530 WP_069589147.1 YifB family Mg chelatase-like AAA ATPase -
Maut_RS06150 1207278..1207802 + 525 WP_011392537.1 hypothetical protein -
Maut_RS06155 1207992..1209092 + 1101 WP_011392538.1 iron-containing alcohol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(11-113)

Antitoxin

SpoVT-AbrB domain

(6-47)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12605.71 Da        Isoelectric Point: 8.4951

>T65810 WP_069589142.1 NZ_CP017019:1204897-1205244 [Moorella thermoacetica]
MVNEMETYIPERGDIVWLQFDPRAGHEQAGRRQALVISPQLYNGKVGLALFCPVTTKAKGYPFEVAIPAGLKITGVILAD
QVKNLDWRAREAQFACKVPAGVVAEVQAKVQVLIS

Download         Length: 348 bp

>T65810 NZ_CP017019:1204897-1205244 [Moorella thermoacetica]
ATGGTAAACGAGATGGAAACCTATATACCCGAACGTGGTGATATAGTCTGGCTCCAGTTTGATCCCCGGGCAGGACATGA
GCAAGCTGGCAGGCGGCAGGCGCTGGTAATTTCACCGCAACTTTATAACGGCAAAGTGGGACTGGCCCTTTTTTGCCCAG
TTACTACAAAGGCGAAGGGTTATCCCTTTGAAGTAGCGATACCGGCTGGTTTAAAGATTACCGGAGTGATCCTGGCAGAC
CAGGTAAAAAACCTTGACTGGCGGGCAAGGGAGGCGCAATTTGCCTGTAAAGTCCCGGCAGGGGTGGTAGCAGAAGTCCA
GGCTAAAGTTCAGGTGTTGATTTCCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8798.14 Da        Isoelectric Point: 7.2029

>AT65810 WP_053094734.1 NZ_CP017019:1204670-1204903 [Moorella thermoacetica]
MQPHVQKWGNSLGIRIPLSLAQKIGLREGTPVDLQVDEDAIIIRRKQYSLEQMLARVKPENIHSEIDTGPQVGREIW

Download         Length: 234 bp

>AT65810 NZ_CP017019:1204670-1204903 [Moorella thermoacetica]
ATGCAACCTCATGTGCAAAAGTGGGGCAATAGTTTAGGGATACGTATCCCTTTGTCGCTAGCCCAAAAAATCGGCCTTAG
AGAAGGCACACCGGTTGATTTACAGGTAGATGAGGACGCGATAATTATCCGCCGCAAACAATACAGCCTGGAACAAATGT
TAGCCCGGGTTAAACCTGAAAATATTCATAGTGAAATAGATACCGGGCCTCAGGTTGGGCGGGAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5D3I7H5

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7X9U1

References