Detailed information of TA system TA065809

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 2293801..2294776
• Replicon: chromosome
• Accession: NZ_CP017016
• Organism: Bacillus sp. ABP14

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: BGI23_RS11940
• Protein ID: WP_070807299.1
• Coordinates: 2293801..2294538 (+)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: R8HWP4
• Locus tag: BGI23_RS11945
• Protein ID: WP_000588712.1
• Coordinates: 2294651..2294776 (+)
• Length: 42 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BGI23_RS11915	2288838..2289245	+	408	WP_044791804.1	VOC family protein	-
BGI23_RS11920	2289530..2290312	+	783	WP_044791803.1	class I SAM-dependent methyltransferase	-
BGI23_RS11925	2290434..2292119	-	1686	WP_070806029.1	alpha-keto acid decarboxylase family protein	-
BGI23_RS11930	2292226..2292708	+	483	WP_000191902.1	MarR family winged helix-turn-helix transcriptional regulator	-
BGI23_RS11935	2292875..2293612	+	738	WP_070806030.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
BGI23_RS11940	2293801..2294538	+	738	WP_070807299.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
BGI23_RS11945	2294651..2294776	+	126	WP_000588712.1	hypothetical protein	Antitoxin
BGI23_RS28410	2294852..2295013	+	162	WP_000852626.1	hypothetical protein	-
BGI23_RS11955	2295050..2295331	-	282	WP_070806031.1	hypothetical protein	-
BGI23_RS28415	2295890..2296066	+	177	WP_000852621.1	hypothetical protein	-
BGI23_RS11965	2296085..2296473	-	389	Protein_2260	YxeA family protein	-
BGI23_RS11970	2296689..2298158	+	1470	WP_070806032.1	beta-Ala-His dipeptidase	-
BGI23_RS11975	2298743..2299213	-	471	WP_070806033.1	DUF5065 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (9-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28301.01 Da
• Isoelectric Point: 8.2638

>T65809 WP_070807299.1 NZ_CP017016:2293801-2294538 [Bacillus sp. ABP14]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNANFRGIRSQFSTIIPLEYIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T65809 NZ_CP017016:2293801-2294538 [Bacillus sp. ABP14]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGGGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATACACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATGCAAACTTTCGCGGTATCCGTTCTCAATTTAGTACGATTATTCCATTAGA
GTACATTGAGCAATTGAATGAGCAGAAAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 42 a.a.
• Molecular weight: 4938.34 Da
• Isoelectric Point: 3.9150

>AT65809 WP_000588712.1 NZ_CP017016:2294651-2294776 [Bacillus sp. ABP14]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Nucleotide

• Length: 126 bp

>AT65809 NZ_CP017016:2294651-2294776 [Bacillus sp. ABP14]
GTGATAAAAGATTATGACAATGATTTTTTCAAAGAAGATAATGAAGATACAACTGATTTCTCTTTAATAAAAGGAGATAC
GTTGCAGCAAGTAGAAGAGTTAGAAGAAGAATTAAAAAGAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A366GQT1