Detailed information of TA system TA065806

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 3167123..3168078
• Replicon: chromosome
• Accession: NZ_CP017014
• Organism: Rhodococcus sp. WMMA185

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: BFN03_RS14235
• Protein ID: WP_070379544.1
• Coordinates: 3167123..3167704 (-)
• Length: 194 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A1D8TC48
• Locus tag: BFN03_RS14240
• Protein ID: WP_070380939.1
• Coordinates: 3167701..3168078 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BFN03_RS14210	3162775..3163548	-	774	WP_070380938.1	response regulator transcription factor	-
BFN03_RS14215	3163686..3164465	+	780	WP_070379540.1	LmeA family phospholipid-binding protein	-
BFN03_RS14220	3164919..3165755	+	837	WP_070379541.1	sulfurtransferase	-
BFN03_RS14225	3165759..3166064	+	306	WP_070379542.1	DUF1416 domain-containing protein	-
BFN03_RS14230	3166386..3167027	+	642	WP_198163497.1	FABP family protein	-
BFN03_RS14235	3167123..3167704	-	582	WP_070379544.1	zeta toxin family protein	Toxin
BFN03_RS14240	3167701..3168078	-	378	WP_070380939.1	hypothetical protein	Antitoxin
BFN03_RS14245	3168402..3170081	-	1680	WP_070380940.1	thiol reductant ABC exporter subunit CydC	-
BFN03_RS14250	3170071..3171774	-	1704	WP_070379545.1	thiol reductant ABC exporter subunit CydD	-
BFN03_RS14255	3171771..3172808	-	1038	WP_070379546.1	cytochrome d ubiquinol oxidase subunit II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (5-157)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (7-62)

Sequences

Toxin

Protein

• Length: 194 a.a.
• Molecular weight: 21212.16 Da
• Isoelectric Point: 4.9562

>T65806 WP_070379544.1 NZ_CP017014:c3167704-3167123 [Rhodococcus sp. WMMA185]
VRRLDLVVGPNGAGKSAFVEQRLAPLLPASVLVNADVIAKDRWPDATEEHSYEAARIAATIRDALIEQGESFIAETVFSH
PSKLELIDRARQAGYVVVLHVVLVPVELAVARVAERVLEGGHSVPEEKIRERFKRLWALVVDAIDRVDHATVYDNTAADV
TRIVARFVDGDAVGEITWPTWTPEELMPTGGHP

Nucleotide

• Length: 582 bp

>T65806 NZ_CP017014:c3167704-3167123 [Rhodococcus sp. WMMA185]
GTGAGACGTCTCGATCTAGTGGTCGGGCCGAACGGCGCCGGCAAGTCGGCCTTCGTCGAGCAACGCCTCGCGCCGCTGCT
GCCCGCAAGCGTATTGGTCAACGCCGACGTGATCGCCAAGGACCGCTGGCCCGACGCAACGGAGGAGCACTCCTACGAGG
CCGCGCGGATCGCAGCGACCATCCGGGACGCCCTGATTGAGCAGGGCGAGTCGTTCATTGCCGAGACCGTGTTTTCGCAC
CCATCGAAATTGGAACTGATCGACCGGGCGCGGCAAGCCGGGTATGTCGTCGTGCTGCACGTGGTCCTGGTGCCAGTCGA
GTTGGCGGTCGCGCGTGTTGCGGAGCGGGTCCTCGAGGGCGGGCATTCGGTGCCCGAGGAGAAGATCCGCGAGCGATTCA
AGCGCCTGTGGGCGCTGGTGGTCGACGCGATTGACCGAGTCGACCACGCGACCGTCTACGACAACACCGCCGCGGACGTT
ACACGGATCGTCGCACGGTTTGTCGACGGTGACGCGGTCGGCGAAATCACCTGGCCCACGTGGACTCCGGAAGAGCTGAT
GCCGACCGGCGGTCATCCGTGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13513.21 Da
• Isoelectric Point: 8.9621

>AT65806 WP_070380939.1 NZ_CP017014:c3168078-3167701 [Rhodococcus sp. WMMA185]
MTAGVDKVTRIASELVDAAAAEGKREHRSARQQLEHWARVGREVSNQRQIARRRVEAALAGRMPLRALSAEEGAVFNAEI
AATLEESLATGNHVADRAAQGRATVSLDEQGRVVKHLPDGTQILL

Nucleotide

• Length: 378 bp

>AT65806 NZ_CP017014:c3168078-3167701 [Rhodococcus sp. WMMA185]
ATGACGGCTGGCGTCGATAAGGTCACCAGGATTGCGTCGGAACTCGTCGATGCGGCGGCAGCCGAGGGTAAGCGCGAGCA
CCGTTCGGCACGTCAGCAGCTCGAACACTGGGCCCGGGTGGGTCGCGAGGTGTCGAACCAGCGACAGATCGCCCGCCGGC
GCGTCGAGGCCGCTCTGGCCGGCCGGATGCCACTGCGTGCACTGTCCGCCGAGGAAGGCGCGGTGTTCAACGCCGAGATA
GCGGCAACACTCGAAGAATCACTCGCAACCGGCAACCATGTCGCCGACCGCGCCGCGCAGGGCCGCGCGACGGTCTCGCT
CGACGAACAGGGCCGCGTCGTCAAGCACCTACCTGACGGCACCCAGATCCTCCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1D8TC48