Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-AbrB
Location 2642465..2643068 Replicon chromosome
Accession NZ_CP017006
Organism Sulfolobus sp. A20

Toxin (Protein)


Gene name vapC Uniprot ID A0A1C8ZVT9
Locus tag BFU36_RS13325 Protein ID WP_069284471.1
Coordinates 2642465..2642857 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1C8ZWJ4
Locus tag BFU36_RS13330 Protein ID WP_069284472.1
Coordinates 2642841..2643068 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFU36_RS13310 (BFU36_13310) 2639766..2639957 - 192 WP_069284468.1 hypothetical protein -
BFU36_RS13315 (BFU36_13315) 2639994..2641421 - 1428 WP_069284469.1 TM1812 family CRISPR-associated protein -
BFU36_RS13320 (BFU36_13320) 2642028..2642456 + 429 WP_069284470.1 hypothetical protein -
BFU36_RS13325 (BFU36_13325) 2642465..2642857 - 393 WP_069284471.1 PIN domain-containing protein Toxin
BFU36_RS13330 (BFU36_13330) 2642841..2643068 - 228 WP_069284472.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BFU36_RS13335 (BFU36_13335) 2643325..2643744 - 420 WP_231961180.1 hypothetical protein -
BFU36_RS14005 2644586..2644756 - 171 WP_156770097.1 hypothetical protein -
BFU36_RS14010 2644953..2645165 - 213 WP_143576911.1 hypothetical protein -
BFU36_RS13340 (BFU36_13340) 2645633..2646307 + 675 WP_069284473.1 metallophosphoesterase -
BFU36_RS13345 (BFU36_13345) 2646397..2647272 - 876 WP_069284474.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(4-48)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14968.35 Da        Isoelectric Point: 4.6547

>T65788 WP_069284471.1 NZ_CP017006:c2642857-2642465 [Sulfolobus sp. A20]
MKVLVDTNVIIFDLIEDSQFHKEAEELLDIAETWVIPSIVIHELVWFLRANNLEDLEYVTAYLGNPKAEVVCDDYEVIRK
AFEIMTREGLSLSRYNDVVILSHAILRKLPLATFDKRLSSLAKKYGINTV

Download         Length: 393 bp

>T65788 NZ_CP017006:c2642857-2642465 [Sulfolobus sp. A20]
ATGAAAGTCTTGGTTGACACTAACGTTATCATTTTTGACCTCATAGAGGATTCACAGTTCCACAAAGAGGCTGAGGAGCT
ACTCGATATAGCTGAAACCTGGGTAATACCTTCAATAGTCATCCACGAATTAGTATGGTTCTTAAGGGCTAACAACTTAG
AGGACTTAGAATACGTAACAGCCTACTTAGGGAACCCAAAGGCTGAGGTAGTCTGTGACGATTATGAAGTGATAAGGAAG
GCATTTGAGATAATGACCAGAGAGGGGCTGTCACTCTCTAGATATAACGACGTGGTCATACTTTCCCACGCTATACTTAG
GAAGTTACCCCTCGCTACCTTTGATAAGAGGCTCTCAAGCCTAGCTAAAAAATACGGCATAAACACTGTATAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8681.12 Da        Isoelectric Point: 9.9123

>AT65788 WP_069284472.1 NZ_CP017006:c2643068-2642841 [Sulfolobus sp. A20]
MERVKVTRNYQITIPSAVRETLGIKEGDILEVYVEGDRIVIKKVKSKRPRIRLNKPVTLEYIDESVERGMHESLG

Download         Length: 228 bp

>AT65788 NZ_CP017006:c2643068-2642841 [Sulfolobus sp. A20]
ATGGAAAGGGTTAAGGTTACTAGGAATTACCAGATAACTATCCCTTCTGCTGTAAGGGAGACTTTAGGGATAAAAGAAGG
AGACATTTTAGAAGTCTACGTCGAGGGTGATAGGATAGTGATAAAGAAGGTCAAGTCTAAGAGACCTAGGATAAGGCTCA
ATAAACCCGTAACTTTGGAATACATAGACGAAAGCGTAGAGAGAGGTATGCATGAAAGTCTTGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C8ZVT9

Antitoxin

Source ID Structure
AlphaFold DB A0A1C8ZWJ4

References