Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_10(toxin)
Location 1427443..1428410 Replicon chromosome
Accession NZ_CP017006
Organism Sulfolobus sp. A20

Toxin (Protein)


Gene name vapC Uniprot ID A0A1C8ZU48
Locus tag BFU36_RS07550 Protein ID WP_069283086.1
Coordinates 1427443..1428051 (-) Length 203 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1C8ZT16
Locus tag BFU36_RS07555 Protein ID WP_069283088.1
Coordinates 1428057..1428410 (-) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFU36_RS07535 (BFU36_07535) 1424008..1424229 + 222 WP_231961080.1 VapB-type antitoxin -
BFU36_RS13835 1424259..1424462 - 204 WP_156770066.1 hypothetical protein -
BFU36_RS07540 (BFU36_07540) 1424834..1425712 - 879 WP_069283084.1 fumarylacetoacetate hydrolase family protein -
BFU36_RS07545 (BFU36_07545) 1425801..1427234 + 1434 WP_069283085.1 aldehyde dehydrogenase family protein -
BFU36_RS07550 (BFU36_07550) 1427443..1428051 - 609 WP_069283086.1 helix-turn-helix domain-containing protein Toxin
BFU36_RS07555 (BFU36_07555) 1428057..1428410 - 354 WP_069283088.1 DUF488 domain-containing protein Antitoxin
BFU36_RS07560 (BFU36_07560) 1428637..1429071 + 435 WP_069283090.1 cation-binding protein -
BFU36_RS07565 (BFU36_07565) 1429136..1429399 + 264 WP_231961082.1 hypothetical protein -
BFU36_RS14255 1429568..1429771 + 204 WP_231961294.1 hypothetical protein -
BFU36_RS07575 (BFU36_07575) 1430137..1430841 - 705 WP_069283094.1 hypothetical protein -
BFU36_RS07580 (BFU36_07580) 1430958..1431548 + 591 WP_069283096.1 hypothetical protein -
BFU36_RS07585 (BFU36_07585) 1431552..1431968 + 417 WP_069283097.1 hemerythrin domain-containing protein -
BFU36_RS07590 (BFU36_07590) 1432007..1432618 + 612 WP_069283101.1 DUF2249 domain-containing protein -
BFU36_RS07595 (BFU36_07595) 1432624..1432989 + 366 WP_069283103.1 metal-sulfur cluster assembly factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterioopsin activator-type, HTH domain

(143-193)

Antitoxin

Protein of unknown function DUF488

(3-108)


Sequences

Toxin        


Download         Length: 203 a.a.        Molecular weight: 23062.06 Da        Isoelectric Point: 9.2681

>T65787 WP_069283086.1 NZ_CP017006:c1428051-1427443 [Sulfolobus sp. A20]
MKQPVEATILIENHPCEVMATFQKLGINANVENIKLRDDVTDHVAELKSNNGKVVEELKKASLKVLRISEDKVWIRTNGC
SVCKLLYHNDVIVEKVKVIGNKSVMYSLMLPNVHSLKKFLEELNNIGVKVTVINISEIDSEELTERQMEILKLAYKLGYF
DVDRRISLRELAEKLGISPPTLEETLRRALKKAVKYYLNKKG

Download         Length: 609 bp

>T65787 NZ_CP017006:c1428051-1427443 [Sulfolobus sp. A20]
ATGAAACAACCCGTTGAGGCTACAATCCTAATAGAGAATCATCCTTGTGAAGTAATGGCAACTTTCCAGAAATTGGGTAT
CAATGCCAATGTGGAGAATATAAAACTGCGTGATGACGTTACTGATCACGTTGCTGAGTTGAAGTCAAATAATGGTAAGG
TTGTTGAAGAGCTTAAGAAAGCCTCGCTTAAAGTTTTAAGAATAAGCGAGGATAAGGTTTGGATAAGGACTAATGGTTGT
AGTGTTTGTAAATTATTATACCACAATGATGTGATTGTGGAAAAAGTGAAAGTCATCGGTAACAAAAGTGTCATGTATTC
CCTAATGTTACCCAACGTGCATTCCCTAAAAAAATTTTTAGAAGAACTGAACAATATAGGAGTTAAAGTAACCGTTATTA
ACATTTCTGAGATAGACAGTGAAGAACTGACTGAGAGGCAAATGGAGATATTGAAGTTAGCTTATAAGTTAGGTTATTTC
GATGTGGATAGGAGAATTTCGTTAAGAGAATTGGCTGAAAAGCTAGGAATAAGCCCACCAACGTTAGAAGAAACGTTAAG
AAGAGCATTAAAGAAGGCAGTTAAATATTATTTAAATAAGAAAGGATAA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 14004.21 Da        Isoelectric Point: 10.1410

>AT65787 WP_069283088.1 NZ_CP017006:c1428410-1428057 [Sulfolobus sp. A20]
MIKVKRVYEKQEKDDGIRILVDRLWPRGIKKNQIDVWLKDIAPSEELRKWFNHDPSKWEEFKARYFNELNNNPKVKVLLE
LVKKSNNITLLYSARSPHNNAIALKEYLENLLKVNES

Download         Length: 354 bp

>AT65787 NZ_CP017006:c1428410-1428057 [Sulfolobus sp. A20]
ATGATAAAAGTAAAAAGAGTGTACGAGAAGCAAGAAAAAGATGATGGAATTAGGATACTAGTTGACAGACTATGGCCTAG
GGGAATTAAGAAAAATCAGATTGATGTTTGGCTTAAAGATATAGCTCCATCAGAGGAATTAAGGAAGTGGTTTAATCATG
ATCCTAGTAAATGGGAGGAATTCAAAGCAAGATATTTTAATGAATTGAATAATAATCCAAAAGTAAAGGTTCTCTTAGAG
CTAGTAAAGAAATCTAATAACATTACCTTGTTATATTCTGCTAGATCACCTCATAATAATGCCATAGCACTTAAGGAATA
TTTGGAAAACTTATTAAAGGTCAATGAGAGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C8ZU48

Antitoxin

Source ID Structure
AlphaFold DB A0A1C8ZT16

References