Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 460017..460555 Replicon chromosome
Accession NZ_CP016988
Organism Vibrio cholerae strain FORC_055 isolate MFDS

Toxin (Protein)


Gene name parE Uniprot ID A0A3Q0L5T8
Locus tag FORC55_RS16890 Protein ID WP_001247271.1
Coordinates 460017..460316 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A7Z7YFC5
Locus tag FORC55_RS16895 Protein ID WP_001107716.1
Coordinates 460313..460555 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC55_RS16835 455494..455991 + 498 WP_000259910.1 GNAT family N-acetyltransferase -
FORC55_RS16850 456645..456926 + 282 WP_080033233.1 DUF1289 domain-containing protein -
FORC55_RS16865 457305..458237 + 933 WP_001267735.1 hypothetical protein -
FORC55_RS16870 458221..458649 + 429 WP_000082746.1 hypothetical protein -
FORC55_RS16875 458867..459124 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FORC55_RS16880 459112..459414 + 303 WP_000818171.1 type II toxin-antitoxin system RelE/ParE family toxin -
FORC55_RS16885 459884..460009 + 126 WP_001933211.1 DUF3265 domain-containing protein -
FORC55_RS16890 460017..460316 - 300 WP_001247271.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC55_RS16895 460313..460555 - 243 WP_001107716.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FORC55_RS16900 461144..463930 + 2787 WP_198302791.1 alkaline phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11703.39 Da        Isoelectric Point: 9.9572

>T65786 WP_001247271.1 NZ_CP016988:c460316-460017 [Vibrio cholerae]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T65786 NZ_CP016988:c460316-460017 [Vibrio cholerae]
ATGAGACCATTTCAGTTAACTAACAAGGCGAAATCTGATTTAAGAGATATAGCCTTGTTTACCTCTCGACGTTGGGGTCG
CGAACAGCGAAATATTTATCTAAAACAGTTTGATGACTCATTTTGGCTGTTAGCCGAAAATCCTGACATTGGTAAAGCCT
GTGACGAAATTCGCGATGGCTACAGAAAGTTTCCACAAGGAAGCCACGTAATATTTTATCGTCAGATCGGCAGTCAAAAT
ATAGAGATTATCCGTATCCTCCACAAAAGCATGGATGTGAATCCAATTTTTGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8895.84 Da        Isoelectric Point: 4.2950

>AT65786 WP_001107716.1 NZ_CP016988:c460555-460313 [Vibrio cholerae]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVAGEESGVADYDLDSFINELDSEERK

Download         Length: 243 bp

>AT65786 NZ_CP016988:c460555-460313 [Vibrio cholerae]
ATGGCTAAGAACACTAGTATTACTTTGGGTGACCATTTTGACGGTTTTATTGCTAATCAAATCCAAAGCGGCCGCTATGG
CTCTGCAAGTGAAGTTATTCGTTCTGCTTTACGTTTACTTGAAACCCAAGAAACTAAAATGAACACTTTACGCCAGTTGC
TTGTTGCGGGCGAAGAAAGTGGAGTTGCGGATTATGACCTTGATTCGTTTATCAATGAGTTAGATAGCGAAGAAAGAAAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5T8

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z7YFC5

References