Detailed information of TA system TA065785

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 458867..459414
• Replicon: chromosome
• Accession: NZ_CP016988
• Organism: Vibrio cholerae strain FORC_055 isolate MFDS

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FORC55_RS16880
• Protein ID: WP_000818171.1
• Coordinates: 459112..459414 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9KM93
• Locus tag: FORC55_RS16875
• Protein ID: WP_000861987.1
• Coordinates: 458867..459124 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC55_RS16825	454731..455009	-	279	WP_000578471.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
FORC55_RS16830	455006..455290	-	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
FORC55_RS16835	455494..455991	+	498	WP_000259910.1	GNAT family N-acetyltransferase	-
FORC55_RS16850	456645..456926	+	282	WP_080033233.1	DUF1289 domain-containing protein	-
FORC55_RS16865	457305..458237	+	933	WP_001267735.1	hypothetical protein	-
FORC55_RS16870	458221..458649	+	429	WP_000082746.1	hypothetical protein	-
FORC55_RS16875	458867..459124	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FORC55_RS16880	459112..459414	+	303	WP_000818171.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FORC55_RS16885	459884..460009	+	126	WP_001933211.1	DUF3265 domain-containing protein	-
FORC55_RS16890	460017..460316	-	300	WP_001247271.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FORC55_RS16895	460313..460555	-	243	WP_001107716.1	type II toxin-antitoxin system ParD family antitoxin	-
FORC55_RS16900	461144..463930	+	2787	WP_198302791.1	alkaline phosphatase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	402484..460316	57832

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11709.57 Da
• Isoelectric Point: 4.8838

>T65785 WP_000818171.1 NZ_CP016988:459112-459414 [Vibrio cholerae]
MAEIVWTEPALSDLNDIAEYIALENVVAAKQLVQTIFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDANV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T65785 NZ_CP016988:459112-459414 [Vibrio cholerae]
ATGGCTGAAATAGTTTGGACGGAACCAGCTCTATCCGATCTAAATGATATTGCTGAATACATAGCGCTTGAAAATGTCGT
AGCTGCTAAACAACTGGTGCAAACTATTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGACGCATTCCAC
CAGAACTAGAGCACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGCCGTGTTTTCTACAAGTATGATGATGCAAATGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9647.15 Da
• Isoelectric Point: 7.3178

>AT65785 WP_000861987.1 NZ_CP016988:458867-459124 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Nucleotide

• Length: 258 bp

>AT65785 NZ_CP016988:458867-459124 [Vibrio cholerae]
ATGAAAGTAGAACTTGTAACTTCACTAAAACGGCAGGCCACTAAGATCCTTGCCGATCTTCATGATACTAAAGAGCCAGT
ATTGATAACTGAGCATGGAAAGCCGTCAGCTTATCTTATTGATGTAGATGATTATGAATTTATGCAAAATCGTTTAGCAA
TCCTCGAAGGAATTGCTCGTGGTGAGCGAGCTCTAGCGGATGGCAAAGTAGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGCTGAAATAG

Structures

Antitoxin

• AlphaFold DB: A0A1T4SLM9