Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /GNAT-DUF1778 |
| Location | 410620..411386 | Replicon | chromosome |
| Accession | NZ_CP016988 | ||
| Organism | Vibrio cholerae strain FORC_055 isolate MFDS | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9K2P7 |
| Locus tag | FORC55_RS16410 | Protein ID | WP_000982260.1 |
| Coordinates | 410620..411117 (-) | Length | 166 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | FORC55_RS16415 | Protein ID | WP_000246252.1 |
| Coordinates | 411114..411386 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC55_RS16350 | 405771..406172 | + | 402 | WP_032475969.1 | hypothetical protein | - |
| FORC55_RS16355 | 406503..406655 | + | 153 | WP_032469020.1 | DUF645 family protein | - |
| FORC55_RS19880 | 406806..406938 | + | 133 | Protein_365 | general secretion pathway protein GspI | - |
| FORC55_RS16365 | 407013..407195 | + | 183 | WP_001966054.1 | DUF645 family protein | - |
| FORC55_RS16375 | 407409..408413 | + | 1005 | WP_000964935.1 | LD-carboxypeptidase | - |
| FORC55_RS16380 | 408555..409052 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| FORC55_RS16385 | 409049..409321 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| FORC55_RS16395 | 409557..409943 | + | 387 | WP_001015079.1 | MmcQ/YjbR family DNA-binding protein | - |
| FORC55_RS16405 | 410181..410420 | + | 240 | WP_000935785.1 | DUF645 family protein | - |
| FORC55_RS16410 | 410620..411117 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | Toxin |
| FORC55_RS16415 | 411114..411386 | - | 273 | WP_000246252.1 | DUF1778 domain-containing protein | Antitoxin |
| FORC55_RS16425 | 411620..412171 | + | 552 | WP_001008563.1 | VRR-NUC domain-containing protein | - |
| FORC55_RS16435 | 412699..413199 | + | 501 | WP_096070910.1 | hypothetical protein | - |
| FORC55_RS16440 | 413381..414730 | + | 1350 | WP_001249388.1 | trypsin-like serine protease | - |
| FORC55_RS19745 | 414818..415003 | + | 186 | WP_145995864.1 | DUF3709 domain-containing protein | - |
| FORC55_RS16445 | 415024..415257 | + | 234 | WP_002033284.1 | DUF3709 domain-containing protein | - |
| FORC55_RS16450 | 415661..415894 | + | 234 | WP_032475975.1 | DUF3709 domain-containing protein | - |
| FORC55_RS19750 | 416083..416277 | + | 195 | WP_080286596.1 | DUF3709 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 402484..460316 | 57832 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 166 a.a. Molecular weight: 18527.18 Da Isoelectric Point: 8.7753
>T65780 WP_000982260.1 NZ_CP016988:c411117-410620 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
Download Length: 498 bp
>T65780 NZ_CP016988:c411117-410620 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATTGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGCGTAGCGTTCCCAGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATTGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGCGTAGCGTTCCCAGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG
Antitoxin
Download Length: 91 a.a. Molecular weight: 9627.11 Da Isoelectric Point: 6.2988
>AT65780 WP_000246252.1 NZ_CP016988:c411386-411114 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAAANAKLKL
ASERYESKTQ
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAAANAKLKL
ASERYESKTQ
Download Length: 273 bp
>AT65780 NZ_CP016988:c411386-411114 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCGGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCGGCAGCAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCGGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCGGCAGCAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|