Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3719786..3720460 Replicon chromosome
Accession NZ_CP016972
Organism Mycobacterium tuberculosis H37Ra

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag BB988_RS18320 Protein ID WP_003417282.1
Coordinates 3719786..3720214 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag BB988_RS18325 Protein ID WP_003417286.1
Coordinates 3720218..3720460 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB988_RS18295 3715608..3716009 - 402 WP_003417264.1 cytidine deaminase -
BB988_RS18300 3716150..3716584 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
BB988_RS18305 3716581..3717015 + 435 WP_009936281.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
BB988_RS18310 3717144..3718916 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
BB988_RS18315 3718916..3719707 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
BB988_RS18320 3719786..3720214 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
BB988_RS18325 3720218..3720460 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
BB988_RS18330 3720582..3721196 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
BB988_RS18335 3721193..3721858 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
BB988_RS18340 3721859..3722392 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
BB988_RS22405 3722389..3722541 - 153 WP_003916129.1 hypothetical protein -
BB988_RS18355 3722577..3723838 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T65766 WP_003417282.1 NZ_CP016972:c3720214-3719786 [Mycobacterium tuberculosis H37Ra]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T65766 NZ_CP016972:c3720214-3719786 [Mycobacterium tuberculosis H37Ra]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT65766 WP_003417286.1 NZ_CP016972:c3720460-3720218 [Mycobacterium tuberculosis H37Ra]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT65766 NZ_CP016972:c3720460-3720218 [Mycobacterium tuberculosis H37Ra]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References