Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1025573..1026546 Replicon chromosome
Accession NZ_CP016972
Organism Mycobacterium tuberculosis H37Ra

Toxin (Protein)


Gene name tacT Uniprot ID O05911
Locus tag BB988_RS05005 Protein ID WP_003404756.1
Coordinates 1026046..1026546 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID O05910
Locus tag BB988_RS05000 Protein ID WP_003898647.1
Coordinates 1025573..1026049 (+) Length 159 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB988_RS04980 1021420..1022691 - 1272 WP_003404747.1 PPE family protein -
BB988_RS04985 1022706..1023005 - 300 WP_003404748.1 PE family protein -
BB988_RS04990 1023449..1025230 + 1782 WP_003404749.1 BCCT family transporter -
BB988_RS04995 1025227..1025484 + 258 WP_003404750.1 hypothetical protein -
BB988_RS05000 1025573..1026049 + 477 WP_003898647.1 DUF1778 domain-containing protein Antitoxin
BB988_RS05005 1026046..1026546 + 501 WP_003404756.1 GNAT family N-acetyltransferase Toxin
BB988_RS05015 1026859..1028178 - 1320 WP_003404757.1 IS256-like element IS1554 family transposase -
BB988_RS05020 1028466..1029047 + 582 WP_003404760.1 IS607-like element IS1535 family transposase -
BB988_RS05025 1029047..1030699 + 1653 WP_003404761.1 IS607 family element transposase accessory protein TnpB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1025227..1071138 45911


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(38-143)

Antitoxin

(74-150)


Sequences


Toxin        


Download         Length: 167 a.a.        Molecular weight: 18048.55 Da        Isoelectric Point: 7.8659

>T65728 WP_003404756.1 NZ_CP016972:1026046-1026546 [Mycobacterium tuberculosis H37Ra]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD

Download         Length: 501 bp

>T65728 NZ_CP016972:1026046-1026546 [Mycobacterium tuberculosis H37Ra]
GTGAGCGGCTACAGCGCGCCGCGACGTATCAGCGACGCCGATGACGTCACGAGCTTCAGCAGCGGCGAGCCCAGTCTGGA
CGATTACTTGCGCAAGCGGGCGTTGGCCAACCATGTGCAGGGAGGGTCGCGCTGTTTCGTGACGTGCCGTGACGGTCGGG
TAGTCGGCTTCTATGCGCTAGCGTCAGGGTCGGTCGCACACGCTGATGCTCCGGGACGGGTGCGCCGCAATATGCCTGAC
CCCGTGCCGGTGATCCTGCTGTCGCGGTTGGCGGTTGATCGCAAAGAACAGGGCAGGGGCCTGGGCAGTCATCTGCTGCG
TGATGCGATCGGTCGCTGTGTCCAGGCTGCGGACTCGATCGGGCTGCGGGCGATTCTTGTTCATGCGTTGCACGATGAGG
CCCGCGCGTTCTACGTCCACTTCGACTTCGAGATCTCGCCGACCGATCCGCTGCACCTAATGCTGTTGATGAAAGACGCT
CGCGCGCTAATTGGCGACTGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 17387.98 Da        Isoelectric Point: 11.2467

>AT65728 WP_003898647.1 NZ_CP016972:1025573-1026049 [Mycobacterium tuberculosis H37Ra]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGSSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG

Download         Length: 477 bp

>AT65728 NZ_CP016972:1025573-1026049 [Mycobacterium tuberculosis H37Ra]
TTGCACCGAGCGGGAGCGGCGGTGACGGCCAACGTGTGGTGTCGTGCGGGCGGCATTCGGATGGCGCCACGGCCGGTCAT
CCCGGTGGCTACGCAGCAGCGCCTGCGGCGGCAGGCGGATCGCCAGAGCCTGGGTAGTAGCGGCTTGCCAGCGTTGAATT
GTACGCCTATCAGGCACACAATTGATGTCATGGCTACCAAGCCTGAGCGGAAGACCGAGCGTCTTGCAGCGCGCCTGACC
CCTGAGCAGGACGCGCTGATTCGTCGTGCTGCCGAGGCCGAGGGGACTGACCTCACCAATTTCACGGTTACAGCGGCGTT
GGCGCACGCGCGCGACGTGCTGGCCGACCGCCGGCTCTTCGTACTCACCGATGCCGCGTGGACTGAGTTCCTCGCCGCGC
TGGACCGGCCCGTCTCACACAAGCCTCGGTTGGAGAAGCTGTTCGCCGCGCGGTCCATTTTCGACACCGAGGGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U4BSZ2


Antitoxin

Source ID Structure
AlphaFold DB A5U0V8

References