Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 445584..446595 Replicon chromosome
Accession NZ_CP016972
Organism Mycobacterium tuberculosis H37Ra

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag BB988_RS01955 Protein ID WP_003401859.1
Coordinates 445584..446177 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag BB988_RS01960 Protein ID WP_003401860.1
Coordinates 446206..446595 (-) Length 130 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB988_RS01935 441233..442615 + 1383 WP_003898415.1 magnesium transporter -
BB988_RS01940 442627..443661 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
BB988_RS01945 443757..444440 + 684 WP_003401857.1 VTT domain-containing protein -
BB988_RS01950 444429..445559 - 1131 WP_003401858.1 hypothetical protein -
BB988_RS01955 445584..446177 - 594 WP_003401859.1 zeta toxin family protein Toxin
BB988_RS01960 446206..446595 - 390 WP_003401860.1 hypothetical protein Antitoxin
BB988_RS01965 446676..447887 - 1212 WP_003906353.1 VWA domain-containing protein -
BB988_RS01970 447893..448495 - 603 WP_003898417.1 SRPBCC family protein -
BB988_RS01975 448509..449405 - 897 WP_003898418.1 MoxR family ATPase -
BB988_RS01980 449402..449995 - 594 WP_003401864.1 NTP transferase domain-containing protein -
BB988_RS01985 449992..450747 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T65713 WP_003401859.1 NZ_CP016972:c446177-445584 [Mycobacterium tuberculosis H37Ra]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T65713 NZ_CP016972:c446177-445584 [Mycobacterium tuberculosis H37Ra]
GTGAAGCGGCTCGATCTGGTCGCCGGGCCCAACGGCGCCGGCAAGTCGACGTTCGTCGCCCTCACGCTGGCGCCCTTGCT
GCCCGGCATCGTCTTCGTCAACGCCGACGAAATCGCCAAACAACGCTGGCCCGACGACCCAACATCGCACGCCTACCAGG
CGGCGCAGGTCGCCGCCGACACCCGCGCGAGGCTCATCGACTTGGGCCGGCCGTTCATTGCCGAGACGGTGTTCTCGCAC
CCATCGAAGCTCGAGCTCATCCGCACCGCGCGCACGGCCGGCTACACCGTCGTACTGCACGTGTTGGTTATCCCCGAAGG
CCTGGCGGTCGAGCGCGTCAGGCATCGCGTCGCCGCGGGCGGCCACGATGTGCCGGAGACCAAGATCCGCGAGCGTCACC
GCCGGCTGGCCGAGCTTGTCGCCCAGGCCATCACGCTGGCCGACGGCGCCACCGTCTATGACAACAGCCGGCTCGCGGGC
CCGCGGATCGTCGCTCAGTTCAGCGGGGGTGGCATCATCGGGCGCGCATGCTGGCCTTCGTGGACGCCGCCACCCTTGAT
GTCACGCTGGAGTAACAGGCCTGAGACGGCGTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT65713 WP_003401860.1 NZ_CP016972:c446595-446206 [Mycobacterium tuberculosis H37Ra]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT65713 NZ_CP016972:c446595-446206 [Mycobacterium tuberculosis H37Ra]
GTGCCCAAAGCCGTCGACCGCGTCACGCGCGTCGCCGCGGATCTGGTGGACAGCGCGGCGGCCGAGGGTGCTCGTCAGAG
CCGTTCGGCCAAGCAGCAGCTCGACCACTGGGCCCGCGTCGGTCGGGCGGTGTCGAACCAGCACACGGCGTCGCGGCGCC
GCGTGGAAGCTGCGCTCGCGGGGCATCTGCCGATGACGGACCTGACGCTGGAGGAGGGCGTGGTGTTCAACGCCGAGATC
TCCGCAGCTATCGAGGAGCGCCTGTCGCGAACCAACTACGGCGACGTGCTCGCCGCGCAGGGCATCACCACGGTCGCCCT
GAACGACGCGGGCGACATCGTCGAGCACCGGCCAGACGGCACCTCGGTCGTGCTGGCGGCCACGCCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References