65712

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 365187..365830 Replicon chromosome
Accession NZ_CP016972
Organism Mycobacterium tuberculosis H37Ra

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag BB988_RS01625 Protein ID WP_003401566.1
Coordinates 365405..365830 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag BB988_RS01620 Protein ID WP_003401563.1
Coordinates 365187..365408 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB988_RS01595 360306..361109 - 804 WP_003401540.1 hypothetical protein -
BB988_RS01600 361119..362516 - 1398 WP_003401544.1 sulfatase -
BB988_RS01605 362695..364470 + 1776 WP_010886074.1 PE family protein -
BB988_RS01610 364613..364840 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
BB988_RS01615 364837..365139 + 303 WP_003401560.1 toxin-antitoxin system toxin -
BB988_RS01620 365187..365408 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
BB988_RS01625 365405..365830 + 426 WP_003401566.1 PIN domain nuclease Toxin
BB988_RS01630 365966..366598 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
BB988_RS01635 366595..367503 + 909 WP_003900117.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T65712 WP_003401566.1 NZ_CP016972:365405-365830 [Mycobacterium tuberculosis H37Ra]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T65712 NZ_CP016972:365405-365830 [Mycobacterium tuberculosis H37Ra]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT65712 WP_003401563.1 NZ_CP016972:365187-365408 [Mycobacterium tuberculosis H37Ra]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT65712 NZ_CP016972:365187-365408 [Mycobacterium tuberculosis H37Ra]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
AlphaFold DB A0A829CG48

References