Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 7218734..7219239 Replicon chromosome
Accession NZ_CP016955
Organism Pseudomonas aeruginosa strain RIVM-EMC2982

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag BFV99_RS35075 Protein ID WP_003083773.1
Coordinates 7218958..7219239 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag BFV99_RS35070 Protein ID WP_003083775.1
Coordinates 7218734..7218961 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFV99_RS35045 7213752..7215245 + 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
BFV99_RS35050 7215414..7216841 + 1428 WP_003083784.1 GABA permease -
BFV99_RS35055 7216923..7217264 - 342 WP_003101229.1 alkylphosphonate utilization protein -
BFV99_RS35060 7217337..7217837 - 501 WP_003101228.1 LEA type 2 family protein -
BFV99_RS35065 7217938..7218558 + 621 WP_003101226.1 hypothetical protein -
BFV99_RS35070 7218734..7218961 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
BFV99_RS35075 7218958..7219239 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
BFV99_RS35080 7219539..7220447 + 909 WP_003083769.1 LysR family transcriptional regulator -
BFV99_RS35085 7220479..7220865 - 387 WP_014602345.1 aegerolysin family protein -
BFV99_RS35090 7221069..7221803 - 735 WP_004346926.1 GntR family transcriptional regulator -
BFV99_RS35095 7221904..7222590 - 687 WP_003083762.1 FadR family transcriptional regulator -
BFV99_RS35100 7222639..7223988 - 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T65682 WP_003083773.1 NZ_CP016955:7218958-7219239 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T65682 NZ_CP016955:7218958-7219239 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT65682 WP_003083775.1 NZ_CP016955:7218734-7218961 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT65682 NZ_CP016955:7218734-7218961 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References