Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4486163..4486679 Replicon chromosome
Accession NZ_CP016955
Organism Pseudomonas aeruginosa strain RIVM-EMC2982

Toxin (Protein)


Gene name relE Uniprot ID A0A3R8UIH5
Locus tag BFV99_RS21305 Protein ID WP_025297453.1
Coordinates 4486163..4486444 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag BFV99_RS21310 Protein ID WP_025297454.1
Coordinates 4486434..4486679 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFV99_RS21285 4481906..4482554 - 649 Protein_4116 peptidase M15 -
BFV99_RS21290 4482578..4484152 - 1575 WP_025297452.1 DNA recombination protein RmuC -
BFV99_RS21295 4484287..4485162 + 876 WP_033895413.1 WYL domain-containing protein -
BFV99_RS21300 4485176..4485757 + 582 WP_033895412.1 plasmid pRiA4b ORF-3 family protein -
BFV99_RS21305 4486163..4486444 - 282 WP_025297453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BFV99_RS21310 4486434..4486679 - 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BFV99_RS21315 4486837..4488978 - 2142 WP_025297455.1 hypothetical protein -
BFV99_RS21320 4489109..4490215 - 1107 WP_025297456.1 XRE family transcriptional regulator -
BFV99_RS21325 4490212..4490880 - 669 WP_071534660.1 hypothetical protein -
BFV99_RS21330 4491228..4491557 + 330 WP_031692728.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4435995..4511179 75184


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.61 Da        Isoelectric Point: 10.6249

>T65678 WP_025297453.1 NZ_CP016955:c4486444-4486163 [Pseudomonas aeruginosa]
MTYELEFLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRASGYRLVYRVEDERVVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

>T65678 NZ_CP016955:c4486444-4486163 [Pseudomonas aeruginosa]
ATGACCTATGAGCTGGAGTTCCTGCCCTCAGCCCTGAAGGAGTGGCAGAAGCTCGGCCATACGGTGCGCGAGCAGATCAA
AAAGAAACTGCGCGAGCGCCTGGATAATCCCAAGGTTCAGGCCGACGCCCTCAGGGATATGCCGGGGCACTACAAAATCA
AGCTGCGTGCATCGGGCTATCGTCTGGTATACCGCGTCGAAGATGAGCGCGTGGTGGTCGTGGTGGTTGCCGTTGGCAAG
CGCGAGCGTGGGGCCGCTTACCAATCTGCCAAGGGCCGTTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT65678 WP_025297454.1 NZ_CP016955:c4486679-4486434 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp

>AT65678 NZ_CP016955:c4486679-4486434 [Pseudomonas aeruginosa]
ATGCAGAGTATCTTGGCTGACGTCGCTGTCAGCGTTTCTGAGTTGAAGAAAAATCCGTCGGGCATCCTGGCTGGTGCAGG
TGGTATGCCTGTCGCCGTGCTCAACCACAATCGCGTCATGGGATACATGGTGCCGGCAGAGCTCTATGAGCAGATGATGG
AGCGCCTAGATGATCTGGAGTTGGTCGAAATAGTGAAGGCTCGCTCGGGCGAGGAGTCTGTCCCGGTGCGTTTGGATGAC
CTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8UIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References