Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1505364..1505978 Replicon chromosome
Accession NZ_CP016955
Organism Pseudomonas aeruginosa strain RIVM-EMC2982

Toxin (Protein)


Gene name hicA Uniprot ID A6VBH9
Locus tag BFV99_RS07075 Protein ID WP_071534354.1
Coordinates 1505364..1505546 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A140SDX7
Locus tag BFV99_RS07080 Protein ID WP_012077229.1
Coordinates 1505574..1505978 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFV99_RS07050 1501005..1501400 + 396 WP_003162782.1 hypothetical protein -
BFV99_RS07055 1501393..1502769 + 1377 WP_003098863.1 class II fumarate hydratase -
BFV99_RS07060 1502797..1503246 + 450 WP_003094369.1 hypothetical protein -
BFV99_RS07065 1503259..1503870 + 612 WP_003098862.1 superoxide dismutase -
BFV99_RS07070 1503889..1504821 + 933 WP_003120918.1 ZIP family metal transporter -
BFV99_RS07075 1505364..1505546 + 183 WP_071534354.1 type II toxin-antitoxin system HicA family toxin Toxin
BFV99_RS07080 1505574..1505978 + 405 WP_012077229.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BFV99_RS07085 1506021..1506992 - 972 WP_012077228.1 hypothetical protein -
BFV99_RS07090 1506977..1507675 - 699 WP_033896049.1 hypothetical protein -
BFV99_RS07095 1507675..1508214 - 540 WP_012074127.1 hypothetical protein -
BFV99_RS07100 1508211..1509131 - 921 WP_012074128.1 hypothetical protein -
BFV99_RS07105 1509128..1509838 - 711 WP_012074129.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1505364..1542858 37494


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6702.74 Da        Isoelectric Point: 10.4826

>T65675 WP_071534354.1 NZ_CP016955:1505364-1505546 [Pseudomonas aeruginosa]
MRSREVIDLLLEDGWYEVAVKGSHHQFKHPSKPGKVTVQHPSSTIPKGTLNNILKQAGLK

Download         Length: 183 bp

>T65675 NZ_CP016955:1505364-1505546 [Pseudomonas aeruginosa]
ATGCGGAGTAGGGAAGTGATTGATTTGCTGTTGGAGGATGGCTGGTATGAAGTGGCGGTGAAAGGTAGCCACCACCAGTT
CAAACATCCTTCAAAGCCTGGAAAGGTGACGGTTCAACATCCGTCCTCGACGATACCGAAAGGAACCCTGAACAACATAC
TGAAACAAGCCGGCCTCAAGTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14670.54 Da        Isoelectric Point: 4.4315

>AT65675 WP_012077229.1 NZ_CP016955:1505574-1505978 [Pseudomonas aeruginosa]
MKFPVVLHKDPDSDYGVTVPDVPGCFSAGATVSEALANVEEALALHFEGLVTDGEELPQPQDVDAHMKNPDFEGGVWAVV
DFDVTPYLGKAVRFNATLPEHLLQRIDERVKVDKRYQSRSGFLATAAMRELSVA

Download         Length: 405 bp

>AT65675 NZ_CP016955:1505574-1505978 [Pseudomonas aeruginosa]
ATGAAATTCCCCGTGGTGTTACACAAAGACCCTGATTCTGACTATGGCGTGACTGTGCCCGATGTGCCGGGTTGCTTCTC
TGCCGGCGCTACGGTGTCCGAGGCCCTGGCCAATGTAGAAGAGGCGCTGGCCTTGCACTTCGAAGGCTTGGTTACGGACG
GCGAAGAGCTACCCCAGCCGCAGGACGTTGACGCCCATATGAAGAATCCGGACTTCGAAGGTGGCGTATGGGCGGTGGTT
GACTTCGACGTGACCCCGTACCTGGGCAAGGCCGTACGCTTTAATGCGACGCTCCCGGAACACCTTCTGCAGCGGATCGA
TGAGCGCGTGAAGGTGGATAAGCGCTATCAGTCTCGGTCGGGCTTTCTGGCAACAGCGGCGATGCGCGAACTGTCAGTGG
CGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6VBH9

Antitoxin

Source ID Structure
AlphaFold DB A0A140SDX7

References