Detailed information of TA system TA065672

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1938554..1939222
• Replicon: chromosome
• Accession: NZ_CP016953
• Organism: Streptococcus himalayensis strain HTS2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A917EGJ9
• Locus tag: BFM96_RS09085
• Protein ID: WP_068993248.1
• Coordinates: 1939043..1939222 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A917AA48
• Locus tag: BFM96_RS09080
• Protein ID: WP_068993245.1
• Coordinates: 1938554..1939003 (-)
• Length: 150 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BFM96_RS09050	1934268..1935758	+	1491	WP_068993232.1	lysine--tRNA ligase	-
BFM96_RS09055	1936062..1936247	+	186	WP_068993235.1	hypothetical protein	-
BFM96_RS09060	1936228..1936578	+	351	WP_068993238.1	IS66 family insertion sequence element accessory protein TnpB	-
BFM96_RS09065	1936630..1936836	+	207	WP_068993241.1	transposase	-
BFM96_RS09070	1936820..1938192	+	1373	Protein_1761	IS66 family transposase	-
BFM96_RS09080	1938554..1939003	-	450	WP_068993245.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BFM96_RS09085	1939043..1939222	-	180	WP_068993248.1	type II toxin-antitoxin system HicA family toxin	Toxin
BFM96_RS09090	1939406..1939804	-	399	WP_068994302.1	hypothetical protein	-
BFM96_RS09095	1940204..1940389	+	186	WP_068993251.1	hypothetical protein	-
BFM96_RS09100	1940370..1940720	+	351	WP_068993254.1	IS66 family insertion sequence element accessory protein TnpB	-
BFM96_RS09105	1940772..1940978	+	207	WP_068993256.1	transposase	-
BFM96_RS09110	1940962..1941684	+	723	WP_189234571.1	transposase	-
BFM96_RS09115	1941757..1942385	+	629	Protein_1769	IS66 family transposase	-
BFM96_RS09120	1942436..1943038	-	603	WP_068993262.1	hypothetical protein	-
BFM96_RS09125	1943079..1943435	-	357	WP_068993265.1	minor capsid protein	-
BFM96_RS11130	1943524..1943691	-	168	WP_145939727.1	DUF2292 domain-containing protein	-
BFM96_RS09130	1943700..1943951	-	252	WP_068993267.1	hypothetical protein	-
BFM96_RS09135	1943953..1944198	-	246	WP_068993270.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1931006..1973849	42843

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (18-114)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6618.80 Da
• Isoelectric Point: 10.9086

>T65672 WP_068993248.1 NZ_CP016953:c1939222-1939043 [Streptococcus himalayensis]
MPMTQKEMVKLLIANGWTKTKGGKGSHVKMEKQGERPITVPHGELNKYTERGIRKQAGI

Nucleotide

• Length: 180 bp

>T65672 NZ_CP016953:c1939222-1939043 [Streptococcus himalayensis]
ATGCCGATGACACAAAAAGAGATGGTAAAACTCCTAATCGCTAATGGTTGGACAAAGACCAAGGGCGGTAAAGGCTCCCA
TGTCAAAATGGAAAAGCAAGGAGAAAGACCCATCACAGTCCCGCATGGTGAACTGAATAAGTACACTGAACGCGGGATAA
GAAAGCAAGCGGGCATTTAG

Antitoxin

Protein

• Length: 150 a.a.
• Molecular weight: 16571.45 Da
• Isoelectric Point: 3.9497

>AT65672 WP_068993245.1 NZ_CP016953:c1939003-1938554 [Streptococcus himalayensis]
MLVTYPALFYYDDTDGTNVPYFVHFPDIDGSGTQGTSLSDAMAMASDWLGIHLAHYIENGQDLPQSSDINSLSLDEDAPF
KDEPDFLSYDPEKSFVSLVMVDVAEYLGNQEPIKKTLTIPRWADKLGRELGLNFSQTLTEAIADKKIQA

Nucleotide

• Length: 450 bp

>AT65672 NZ_CP016953:c1939003-1938554 [Streptococcus himalayensis]
ATGTTAGTTACTTATCCAGCCTTATTTTATTATGATGATACAGATGGGACTAACGTGCCTTACTTTGTACATTTTCCAGA
TATTGATGGTTCGGGCACTCAAGGTACAAGCCTTTCGGACGCTATGGCGATGGCTAGTGACTGGCTAGGTATTCATCTGG
CGCATTATATCGAGAACGGTCAAGACCTACCGCAATCATCAGACATCAATAGTCTTTCATTGGATGAAGATGCCCCATTT
AAAGATGAACCCGATTTTTTATCTTATGACCCTGAAAAATCCTTTGTCTCGCTTGTTATGGTTGATGTTGCGGAGTATCT
AGGAAACCAAGAGCCGATAAAAAAAACTTTAACCATTCCACGTTGGGCGGACAAATTGGGGCGTGAGTTAGGTTTGAATT
TTTCTCAGACACTCACCGAAGCCATTGCAGATAAGAAAATACAAGCCTAG