Detailed information of TA system TA065671

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1420249..1420732
• Replicon: chromosome
• Accession: NZ_CP016953
• Organism: Streptococcus himalayensis strain HTS2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A917AA61
• Locus tag: BFM96_RS06600
• Protein ID: WP_068991936.1
• Coordinates: 1420472..1420732 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BFM96_RS06595
• Protein ID: WP_024532383.1
• Coordinates: 1420249..1420470 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BFM96_RS10935	1415539..1416156	+	618	WP_188595320.1	DnaD domain protein	-
BFM96_RS06555	1416167..1416994	+	828	WP_068991915.1	ATP-binding protein	-
BFM96_RS06560	1417097..1417327	+	231	WP_068991918.1	hypothetical protein	-
BFM96_RS06565	1417566..1417748	+	183	WP_068991920.1	hypothetical protein	-
BFM96_RS06570	1417845..1418423	+	579	WP_068994227.1	hypothetical protein	-
BFM96_RS06575	1418420..1418707	+	288	WP_068991922.1	hypothetical protein	-
BFM96_RS06580	1418745..1419158	+	414	WP_068991925.1	replication protein	-
BFM96_RS06585	1419166..1419492	+	327	WP_068991929.1	hypothetical protein	-
BFM96_RS06590	1419510..1419920	+	411	WP_068991933.1	hypothetical protein	-
BFM96_RS06595	1420249..1420470	+	222	WP_024532383.1	hypothetical protein	Antitoxin
BFM96_RS06600	1420472..1420732	+	261	WP_068991936.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BFM96_RS06605	1420998..1422341	+	1344	Protein_1266	IS1182 family transposase	-
BFM96_RS06610	1422925..1423920	-	996	WP_068991938.1	DNA/RNA non-specific endonuclease	-
BFM96_RS06615	1424047..1424694	-	648	WP_068991939.1	hemolysin III family protein	-
BFM96_RS06620	1424672..1425133	-	462	WP_068991942.1	DUF1836 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1410600..1425947	15347
	-	flank	IS/Tn	-	-	1420998..1422440	1442

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10281.81 Da
• Isoelectric Point: 9.6749

>T65671 WP_068991936.1 NZ_CP016953:1420472-1420732 [Streptococcus himalayensis]
MYSIEYSKKAQKQIKKLDKQIQRLLFAWIDKHLEGTDNPRAHGKGLTGNHANEWRYRIGDYRFICDIQDDKMVILALEFG
HRKDIY

Nucleotide

• Length: 261 bp

>T65671 NZ_CP016953:1420472-1420732 [Streptococcus himalayensis]
ATGTACAGTATAGAGTATTCTAAAAAGGCTCAAAAGCAGATTAAGAAACTAGATAAGCAGATACAGCGGTTGTTATTCGC
TTGGATTGATAAACACTTAGAGGGGACAGACAATCCACGCGCCCATGGTAAAGGTTTAACAGGGAACCATGCTAACGAAT
GGCGTTACCGTATTGGTGATTATAGGTTTATATGTGATATTCAAGATGATAAAATGGTTATTCTAGCTCTTGAGTTTGGG
CATAGGAAAGATATTTACTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8515.55 Da
• Isoelectric Point: 4.6128

>AT65671 WP_024532383.1 NZ_CP016953:1420249-1420470 [Streptococcus himalayensis]
MSTVTIRLNQEEETFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYKQAYAEYKADPETISHADFKKELGL

Nucleotide

• Length: 222 bp

>AT65671 NZ_CP016953:1420249-1420470 [Streptococcus himalayensis]
ATGAGTACAGTAACTATCAGATTAAATCAAGAAGAAGAAACATTTTTCAAAAGCTATGCTCAATTAACAGGGCAAAGCCT
TTCAAGTCTTTTCAAGAAAGCCCTAGAGCGTGATATTGAAGACGAGTATGATTTGAAAATCTATAAACAAGCCTATGCAG
AGTATAAGGCAGATCCAGAGACAATTAGCCATGCTGATTTTAAGAAAGAGCTAGGCTTGTAA