Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1920954..1921608 Replicon chromosome
Accession NZ_CP016952
Organism Citrobacter freundii strain SL151

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag BFQ28_RS09155 Protein ID WP_003026936.1
Coordinates 1921201..1921608 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag BFQ28_RS09150 Protein ID WP_003026938.1
Coordinates 1920954..1921220 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFQ28_RS09125 1916153..1917586 - 1434 WP_069219487.1 6-phospho-beta-glucosidase BglA -
BFQ28_RS09130 1917708..1918436 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
BFQ28_RS09135 1918489..1918800 + 312 WP_003026949.1 N(4)-acetylcytidine aminohydrolase -
BFQ28_RS09140 1918964..1919623 + 660 WP_046670319.1 hemolysin III family protein -
BFQ28_RS09145 1919717..1920697 - 981 WP_003026944.1 tRNA-modifying protein YgfZ -
BFQ28_RS09150 1920954..1921220 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
BFQ28_RS09155 1921201..1921608 + 408 WP_003026936.1 protein YgfX Toxin
BFQ28_RS09160 1921653..1922174 - 522 WP_003026933.1 flavodoxin FldB -
BFQ28_RS09165 1922288..1923184 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
BFQ28_RS09170 1923208..1923921 + 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BFQ28_RS09175 1923927..1925660 + 1734 WP_016150943.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T65658 WP_003026936.1 NZ_CP016952:1921201-1921608 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

>T65658 NZ_CP016952:1921201-1921608 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTCGGCTGTTGATGGATGGCCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCTGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT65658 WP_003026938.1 NZ_CP016952:1920954-1921220 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT65658 NZ_CP016952:1920954-1921220 [Citrobacter freundii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGAGGTATGCGCGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTGAGCTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References