Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 325670..326199 Replicon plasmid unnamed
Accession NZ_CP016951
Organism Cupriavidus taiwanensis strain SWF66294

Toxin (Protein)


Gene name relE Uniprot ID B2AJR7
Locus tag A9P79_RS29850 Protein ID WP_012354431.1
Coordinates 325930..326199 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID B2AJR8
Locus tag A9P79_RS29845 Protein ID WP_012354432.1
Coordinates 325670..325933 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9P79_RS29830 (A9P79_29050) 320830..321516 - 687 WP_012354436.1 DUF4194 domain-containing protein -
A9P79_RS29835 (A9P79_29055) 321509..322939 - 1431 WP_012354435.1 DUF5716 family protein -
A9P79_RS29840 (A9P79_29060) 323314..325353 - 2040 WP_240074705.1 hypothetical protein -
A9P79_RS29845 (A9P79_29065) 325670..325933 + 264 WP_012354432.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
A9P79_RS29850 (A9P79_29070) 325930..326199 + 270 WP_012354431.1 Txe/YoeB family addiction module toxin Toxin
A9P79_RS29855 (A9P79_29075) 326575..327144 + 570 WP_012354430.1 TetR/AcrR family transcriptional regulator -
A9P79_RS29860 (A9P79_29080) 327196..328203 + 1008 WP_115671161.1 dienelactone hydrolase family protein -
A9P79_RS29865 (A9P79_29085) 328678..329478 + 801 WP_012354428.1 YecA family protein -
A9P79_RS29870 (A9P79_29090) 330349..330594 - 246 WP_018003930.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..578456 578456


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10553.90 Da        Isoelectric Point: 6.9767

>T65650 WP_012354431.1 NZ_CP016951:325930-326199 [Cupriavidus taiwanensis]
MTRRLTFMPDAWEDYVYWQGQDRKTLKRINALIQDAQREPFDGLGKPEPLKGNLSGYWSRRIDDSNRLVYFANDDELTII
ACRLHYGDK

Download         Length: 270 bp

>T65650 NZ_CP016951:325930-326199 [Cupriavidus taiwanensis]
ATGACGCGCCGGTTGACCTTTATGCCAGATGCCTGGGAAGACTATGTCTATTGGCAGGGCCAAGACAGGAAAACGCTCAA
GCGCATCAACGCCCTAATCCAGGACGCCCAACGCGAACCGTTCGACGGGCTCGGCAAGCCCGAGCCGCTGAAAGGCAACC
TGTCGGGCTACTGGTCGCGGCGAATCGACGACAGCAACCGCTTGGTGTATTTCGCCAACGACGATGAACTGACCATTATC
GCTTGTCGGCTTCATTATGGCGACAAGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9884.12 Da        Isoelectric Point: 5.4637

>AT65650 WP_012354432.1 NZ_CP016951:325670-325933 [Cupriavidus taiwanensis]
MRTIHFSDARSNLKAVMDQAIDDHDAVLITRRDAPNVVIMSQDQYDSWMETMHLLSSPANAARLLRSIQQHRAGMAEKHD
LIDPDAE

Download         Length: 264 bp

>AT65650 NZ_CP016951:325670-325933 [Cupriavidus taiwanensis]
ATGCGTACCATCCATTTCTCCGACGCCCGCAGCAACCTAAAGGCAGTCATGGACCAGGCCATCGACGACCACGACGCTGT
GCTCATCACACGCCGCGACGCGCCGAACGTGGTCATCATGTCGCAAGACCAGTACGACAGTTGGATGGAAACGATGCATT
TGCTTAGCTCGCCGGCTAACGCCGCGCGCCTGCTGCGTTCTATTCAGCAGCATCGCGCTGGCATGGCCGAGAAGCACGAC
CTGATCGACCCGGACGCTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A375HUY1

Antitoxin

Source ID Structure
AlphaFold DB A0A375HVQ5

References