Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 301537..302573 | Replicon | plasmid unnamed |
| Accession | NZ_CP016951 | ||
| Organism | Cupriavidus taiwanensis strain SWF66294 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | A9P79_RS29740 | Protein ID | WP_018003706.1 |
| Coordinates | 301537..302109 (-) | Length | 191 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | F8GXU6 |
| Locus tag | A9P79_RS29745 | Protein ID | WP_012354456.1 |
| Coordinates | 302112..302573 (-) | Length | 154 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A9P79_RS29715 (A9P79_28940) | 297125..297328 | + | 204 | WP_018003739.1 | hypothetical protein | - |
| A9P79_RS29720 (A9P79_28945) | 297309..297755 | + | 447 | Protein_285 | AMP-binding protein | - |
| A9P79_RS29725 (A9P79_28950) | 297810..299069 | + | 1260 | WP_012354364.1 | IS256 family transposase | - |
| A9P79_RS29730 | 299542..300150 | - | 609 | WP_018003705.1 | restriction endonuclease | - |
| A9P79_RS29735 (A9P79_28960) | 300707..301279 | + | 573 | WP_012354459.1 | cold shock and DUF1294 domain-containing protein | - |
| A9P79_RS29740 (A9P79_28965) | 301537..302109 | - | 573 | WP_018003706.1 | PIN domain-containing protein | Toxin |
| A9P79_RS29745 (A9P79_28970) | 302112..302573 | - | 462 | WP_012354456.1 | excisionase family DNA-binding protein | Antitoxin |
| A9P79_RS29750 (A9P79_28975) | 302939..303403 | - | 465 | WP_018003707.1 | PliI family lysozyme inhibitor of I-type lysozyme | - |
| A9P79_RS29755 | 303504..303894 | + | 391 | Protein_292 | ISKra4 family transposase | - |
| A9P79_RS29760 (A9P79_28985) | 304377..305540 | - | 1164 | WP_012354452.1 | porin | - |
| A9P79_RS29765 (A9P79_28990) | 305849..306211 | + | 363 | WP_012354450.1 | hypothetical protein | - |
| A9P79_RS29770 (A9P79_28995) | 306455..306724 | - | 270 | WP_012354448.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..578456 | 578456 | |
| - | flank | IS/Tn | - | - | 297810..299069 | 1259 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 191 a.a. Molecular weight: 21290.32 Da Isoelectric Point: 5.0352
>T65649 WP_018003706.1 NZ_CP016951:c302109-301537 [Cupriavidus taiwanensis]
MTSNFAVVYDACVLYPAPLRDLLMRLALTDLYRAKWTNQIHDEWVRNLLARRPELSADRLAGTRELMNRSVRDSLVFGYE
HLIESIELPDPDDRHVVAAAIHSGSEAIITFNMKDFPEAALKEFNVEAIHPDDFVVDLFDLNAGKVLAAVADHRASLKNP
PKSPSEYLTTLSAQGLTQTVLILTQYSLAI
MTSNFAVVYDACVLYPAPLRDLLMRLALTDLYRAKWTNQIHDEWVRNLLARRPELSADRLAGTRELMNRSVRDSLVFGYE
HLIESIELPDPDDRHVVAAAIHSGSEAIITFNMKDFPEAALKEFNVEAIHPDDFVVDLFDLNAGKVLAAVADHRASLKNP
PKSPSEYLTTLSAQGLTQTVLILTQYSLAI
Download Length: 573 bp
>T65649 NZ_CP016951:c302109-301537 [Cupriavidus taiwanensis]
ATGACCTCCAACTTCGCTGTCGTCTACGATGCTTGCGTTCTCTATCCTGCTCCGCTGCGCGATCTGCTGATGCGGCTCGC
GCTGACCGACCTGTACCGTGCAAAATGGACGAATCAAATTCATGACGAGTGGGTTCGCAACCTCCTCGCGCGGCGGCCGG
AGCTTTCCGCGGATCGTCTTGCAGGCACGCGCGAACTGATGAACCGAAGCGTTCGCGATTCGCTAGTTTTCGGCTATGAA
CACCTTATTGAGTCCATTGAGTTGCCTGACCCTGACGATCGACATGTGGTCGCGGCCGCAATTCATAGCGGCTCGGAGGC
AATCATCACCTTCAATATGAAGGACTTTCCGGAAGCAGCGCTCAAGGAGTTCAACGTCGAAGCGATCCACCCGGACGATT
TCGTCGTGGACCTCTTTGATCTGAATGCAGGGAAGGTCCTAGCGGCAGTGGCGGACCACCGTGCATCTCTGAAGAATCCA
CCGAAGTCTCCTTCGGAGTATTTGACCACCCTTTCGGCGCAAGGCCTGACGCAAACGGTGTTGATCCTAACGCAGTACAG
TTTGGCAATCTGA
ATGACCTCCAACTTCGCTGTCGTCTACGATGCTTGCGTTCTCTATCCTGCTCCGCTGCGCGATCTGCTGATGCGGCTCGC
GCTGACCGACCTGTACCGTGCAAAATGGACGAATCAAATTCATGACGAGTGGGTTCGCAACCTCCTCGCGCGGCGGCCGG
AGCTTTCCGCGGATCGTCTTGCAGGCACGCGCGAACTGATGAACCGAAGCGTTCGCGATTCGCTAGTTTTCGGCTATGAA
CACCTTATTGAGTCCATTGAGTTGCCTGACCCTGACGATCGACATGTGGTCGCGGCCGCAATTCATAGCGGCTCGGAGGC
AATCATCACCTTCAATATGAAGGACTTTCCGGAAGCAGCGCTCAAGGAGTTCAACGTCGAAGCGATCCACCCGGACGATT
TCGTCGTGGACCTCTTTGATCTGAATGCAGGGAAGGTCCTAGCGGCAGTGGCGGACCACCGTGCATCTCTGAAGAATCCA
CCGAAGTCTCCTTCGGAGTATTTGACCACCCTTTCGGCGCAAGGCCTGACGCAAACGGTGTTGATCCTAACGCAGTACAG
TTTGGCAATCTGA
Antitoxin
Download Length: 154 a.a. Molecular weight: 17046.22 Da Isoelectric Point: 5.0133
>AT65649 WP_012354456.1 NZ_CP016951:c302573-302112 [Cupriavidus taiwanensis]
MHATITNTTLPSADESAIARESSRSLAVALDSRSDTQQFDFKTDKGELHSVTLPTSALRLLVEVLAEIGQGNAVSIIPIH
AELTTQEAADLLNVSRPYLVQLLEKGEIPFRKVNTHRRVLYQDVVSYKQRIDDERRKALDELAAQAQELDMGY
MHATITNTTLPSADESAIARESSRSLAVALDSRSDTQQFDFKTDKGELHSVTLPTSALRLLVEVLAEIGQGNAVSIIPIH
AELTTQEAADLLNVSRPYLVQLLEKGEIPFRKVNTHRRVLYQDVVSYKQRIDDERRKALDELAAQAQELDMGY
Download Length: 462 bp
>AT65649 NZ_CP016951:c302573-302112 [Cupriavidus taiwanensis]
ATGCACGCAACCATCACTAACACGACGCTGCCTTCGGCAGACGAAAGCGCTATCGCTCGGGAATCGAGCCGTAGCCTGGC
GGTGGCACTGGACAGCCGATCCGATACGCAGCAATTCGATTTCAAGACTGACAAGGGCGAGTTGCATAGTGTCACATTGC
CCACCTCTGCTCTGAGGCTTCTCGTCGAGGTTCTCGCCGAAATCGGCCAAGGGAACGCCGTCTCCATCATTCCAATTCAC
GCCGAGCTGACGACGCAAGAGGCGGCGGACCTGCTTAACGTCTCTCGCCCATACTTGGTTCAACTTCTGGAGAAGGGCGA
GATTCCGTTCCGTAAAGTCAACACGCATCGGCGCGTCCTCTACCAGGACGTTGTCAGCTACAAGCAGCGCATTGATGACG
AGCGACGCAAGGCACTAGACGAACTCGCAGCGCAGGCCCAAGAGTTGGACATGGGCTATTGA
ATGCACGCAACCATCACTAACACGACGCTGCCTTCGGCAGACGAAAGCGCTATCGCTCGGGAATCGAGCCGTAGCCTGGC
GGTGGCACTGGACAGCCGATCCGATACGCAGCAATTCGATTTCAAGACTGACAAGGGCGAGTTGCATAGTGTCACATTGC
CCACCTCTGCTCTGAGGCTTCTCGTCGAGGTTCTCGCCGAAATCGGCCAAGGGAACGCCGTCTCCATCATTCCAATTCAC
GCCGAGCTGACGACGCAAGAGGCGGCGGACCTGCTTAACGTCTCTCGCCCATACTTGGTTCAACTTCTGGAGAAGGGCGA
GATTCCGTTCCGTAAAGTCAACACGCATCGGCGCGTCCTCTACCAGGACGTTGTCAGCTACAAGCAGCGCATTGATGACG
AGCGACGCAAGGCACTAGACGAACTCGCAGCGCAGGCCCAAGAGTTGGACATGGGCTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|