Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2608345..2608993 Replicon chromosome
Accession NZ_CP016950
Organism Cupriavidus taiwanensis strain SWF66294

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A9P79_RS24045 Protein ID WP_240072512.1
Coordinates 2608568..2608993 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag A9P79_RS24040 Protein ID WP_240074669.1
Coordinates 2608345..2608581 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9P79_RS24025 (A9P79_23685) 2603929..2605347 + 1419 WP_115704388.1 argininosuccinate lyase -
A9P79_RS24030 (A9P79_23690) 2605641..2606240 + 600 WP_240072511.1 TRAP transporter small permease subunit -
A9P79_RS24035 (A9P79_23695) 2606253..2607971 + 1719 WP_115704392.1 TRAP transporter large permease subunit -
A9P79_RS24040 (A9P79_23700) 2608345..2608581 + 237 WP_240074669.1 DNA-binding protein Antitoxin
A9P79_RS24045 (A9P79_23705) 2608568..2608993 + 426 WP_240072512.1 type II toxin-antitoxin system VapC family toxin Toxin
A9P79_RS24050 (A9P79_23710) 2609048..2611318 - 2271 WP_240072513.1 arginine/lysine/ornithine decarboxylase -
A9P79_RS24055 (A9P79_23715) 2611466..2612032 - 567 WP_115661373.1 dCTP deaminase -
A9P79_RS24060 (A9P79_23720) 2612128..2612958 - 831 WP_240072514.1 formate dehydrogenase accessory sulfurtransferase FdhD -
A9P79_RS24065 (A9P79_23725) 2613015..2613374 - 360 WP_115704400.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15740.08 Da        Isoelectric Point: 10.6414

>T65648 WP_240072512.1 NZ_CP016950:2608568-2608993 [Cupriavidus taiwanensis]
VYLIDTNVISETRKRERANPGVRAFFRQAARDGTALYLSALTVGELQRGVALIRHRGDAVQAALLERWLAHVLEDFGRHV
LPVDAEVAQVWGQLRAARPEHALDKFIAATALIHRLTIVTRNVADFRGTGTMVMNPFSQDK

Download         Length: 426 bp

>T65648 NZ_CP016950:2608568-2608993 [Cupriavidus taiwanensis]
GTGTATTTGATTGATACCAACGTCATCAGCGAGACCCGCAAGCGGGAGCGCGCCAACCCCGGCGTCCGCGCCTTCTTCCG
GCAGGCAGCGCGCGATGGGACCGCGCTCTACCTGTCGGCGCTGACCGTGGGCGAACTCCAGCGCGGCGTGGCCCTGATCC
GTCATCGCGGCGACGCGGTGCAGGCGGCGCTGCTGGAGCGCTGGCTGGCCCATGTGCTGGAGGACTTCGGGCGCCATGTG
CTGCCGGTCGATGCCGAGGTCGCGCAGGTCTGGGGCCAGTTGCGCGCGGCGCGGCCCGAGCACGCGCTGGACAAGTTCAT
CGCCGCCACCGCGCTGATCCACCGCCTCACCATCGTCACGCGCAATGTCGCGGACTTCCGCGGCACCGGCACGATGGTGA
TGAATCCGTTCAGCCAGGACAAATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8412.38 Da        Isoelectric Point: 5.0747

>AT65648 WP_240074669.1 NZ_CP016950:2608345-2608581 [Cupriavidus taiwanensis]
MATLLVRGVDEALVQRLREQAAANGRSAEAEHRAILAHALGGTARRSFAEVLSGMPEVGHDADFERIQDTGEAPRVFD

Download         Length: 237 bp

>AT65648 NZ_CP016950:2608345-2608581 [Cupriavidus taiwanensis]
ATGGCAACCCTACTGGTTCGTGGCGTCGATGAAGCGCTGGTCCAGCGCCTGCGCGAGCAGGCCGCGGCCAATGGCCGCAG
CGCCGAGGCCGAACACCGCGCCATCCTGGCGCATGCGTTGGGCGGCACGGCCCGGCGCAGCTTTGCCGAAGTGCTGTCCG
GCATGCCCGAGGTCGGGCATGACGCCGACTTCGAGCGCATCCAGGATACGGGCGAGGCGCCGCGTGTATTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References