65645

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1742807..1744491 Replicon chromosome
Accession NZ_CP016950
Organism Cupriavidus taiwanensis strain SWF66294

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag A9P79_RS20040 Protein ID WP_172582511.1
Coordinates 1743145..1744491 (+) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag A9P79_RS20035 Protein ID WP_115703227.1
Coordinates 1742807..1743142 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9P79_RS20010 (A9P79_19715) 1738253..1738774 + 522 WP_240074595.1 tail fiber protein -
A9P79_RS20015 (A9P79_19720) 1738791..1739309 + 519 WP_240074644.1 GNAT family N-acetyltransferase -
A9P79_RS20020 (A9P79_19725) 1739611..1740840 + 1230 WP_240074596.1 hypothetical protein -
A9P79_RS20025 (A9P79_19730) 1740871..1741722 - 852 WP_240074597.1 helix-turn-helix transcriptional regulator -
A9P79_RS20030 (A9P79_19735) 1741927..1742613 + 687 WP_240074598.1 hypothetical protein -
A9P79_RS20035 (A9P79_19740) 1742807..1743142 + 336 WP_115703227.1 helix-turn-helix transcriptional regulator Antitoxin
A9P79_RS20040 (A9P79_19745) 1743145..1744491 + 1347 WP_172582511.1 type II toxin-antitoxin system HipA family toxin Toxin
A9P79_RS20060 (A9P79_19765) 1745091..1747253 + 2163 WP_240074599.1 acetate--CoA ligase family protein -
A9P79_RS20065 (A9P79_19770) 1747250..1748245 + 996 WP_115703233.1 tripartite tricarboxylate transporter substrate binding protein -
A9P79_RS20070 (A9P79_19775) 1748269..1749153 + 885 WP_115703235.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 49240.99 Da        Isoelectric Point: 8.5016

>T65645 WP_172582511.1 NZ_CP016950:1743145-1744491 [Cupriavidus taiwanensis]
MARARQGNRLDLWMNGIPVGHWETGAGGDRLVYREDWIADPQGRPLSLSLPFTPGNQPHRGPAVANYFDNLLPDSDVIRR
RIAARYRAGGTDAFALLARVGRDCVGAIQMLPPGEVPEALQTVSGRTLSDEDIATLLHETTSAPVLGHREPIDDLRLSIA
GAQEKTALLRWRGQWQLPQGSTPTTHIFKLPLGLVGNMRADMRTSVENEWLCAQIVAAYGLPVAQCEIARFAGTKALVVE
RFDRRPSSRGTWLLRLPQEDMCQATGLSALQKYESDGGPGIRQIAEILSGSRAAAADRRHFFMAQVVFWLLAATDGHAKN
FSISHLPGSQYEATPLYDVLSAHPVIGRGRNQLAPQKARLAMALHGRNSHYAIHEIRRRHWFAQGQRIGFSPAEVEAILD
HVTGQTAQVIDTVASALPADFPLDVADAIFDGMRRHNRKLAARAEADL

Download         Length: 1347 bp

>T65645 NZ_CP016950:1743145-1744491 [Cupriavidus taiwanensis]
ATGGCGCGCGCACGGCAAGGCAACCGGCTCGACCTGTGGATGAACGGCATCCCGGTCGGCCATTGGGAAACCGGCGCCGG
CGGTGACCGGCTGGTCTATCGCGAAGACTGGATCGCCGACCCGCAGGGACGCCCACTGTCGTTGTCGCTGCCGTTCACGC
CTGGCAACCAGCCGCATCGCGGCCCGGCTGTGGCCAACTATTTCGACAACCTGCTGCCCGACAGCGATGTCATCCGCCGC
CGCATCGCGGCACGCTATCGTGCCGGCGGCACCGACGCCTTCGCGCTGCTGGCCAGGGTGGGACGCGACTGCGTCGGCGC
GATCCAGATGCTGCCGCCTGGCGAAGTGCCCGAGGCACTGCAGACGGTCAGCGGCCGCACGCTCAGCGACGAAGACATTG
CGACGCTGCTGCACGAAACCACGTCGGCGCCGGTGCTCGGGCATCGCGAGCCCATCGACGACCTGAGGCTATCGATCGCC
GGCGCGCAGGAGAAAACCGCGCTGCTGCGCTGGCGCGGACAATGGCAGCTGCCCCAGGGCAGCACGCCGACCACGCATAT
CTTCAAGCTGCCGCTCGGGCTGGTGGGCAATATGCGCGCCGACATGCGCACCTCGGTGGAAAACGAATGGCTGTGCGCGC
AGATCGTGGCGGCTTATGGCCTGCCGGTGGCGCAGTGCGAGATCGCCCGCTTTGCCGGCACCAAGGCGCTGGTGGTCGAA
CGCTTCGACCGCAGGCCGTCGAGCCGCGGCACCTGGCTGCTGCGCCTGCCGCAGGAAGACATGTGCCAGGCCACCGGCCT
CTCGGCCTTGCAGAAATACGAGTCCGACGGCGGACCCGGCATCCGGCAGATTGCCGAGATCCTGTCCGGCTCGCGCGCGG
CGGCCGCCGACCGCCGGCATTTCTTCATGGCTCAGGTGGTGTTCTGGCTGCTGGCGGCAACCGATGGCCATGCCAAGAAT
TTCAGCATCAGCCACTTGCCGGGCAGCCAGTATGAGGCGACGCCGCTGTACGACGTGCTGTCGGCGCATCCGGTGATCGG
CCGCGGCCGCAACCAGCTGGCGCCGCAGAAGGCCCGGCTGGCGATGGCGCTGCATGGCCGCAACAGCCACTACGCCATCC
ACGAAATCCGCCGGCGCCACTGGTTTGCACAGGGACAGCGCATCGGCTTCTCTCCCGCCGAGGTAGAGGCCATCCTGGAC
CACGTGACCGGGCAGACCGCGCAGGTGATCGACACGGTCGCGTCGGCATTGCCGGCGGACTTTCCGCTGGATGTGGCCGA
CGCGATCTTCGACGGCATGCGCCGGCACAACCGCAAGCTGGCGGCGCGGGCCGAGGCGGACCTGTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12185.04 Da        Isoelectric Point: 11.6656

>AT65645 WP_115703227.1 NZ_CP016950:1742807-1743142 [Cupriavidus taiwanensis]
MHYPIKTANQLRPILQGFRKSRGMTQAVMAQHLGVTQQTYAELEANPAAVSVDRLLRVLRVLGVELVLSQADAGATAQPA
PVRPQAKPRAPANKTEQPARPATGRRPREDW

Download         Length: 336 bp

>AT65645 NZ_CP016950:1742807-1743142 [Cupriavidus taiwanensis]
ATGCACTACCCCATCAAGACCGCCAACCAGTTGCGTCCGATTCTGCAGGGCTTCCGCAAGTCGCGCGGCATGACCCAGGC
CGTGATGGCACAGCACCTCGGGGTCACGCAGCAAACCTATGCCGAACTGGAAGCTAACCCCGCCGCCGTCAGCGTCGACC
GCCTGCTGCGGGTGCTGCGCGTGCTCGGCGTCGAACTCGTGCTGTCGCAGGCGGACGCTGGCGCCACCGCGCAGCCCGCA
CCAGTCCGACCCCAGGCCAAGCCCAGGGCGCCGGCAAACAAGACCGAGCAGCCGGCCCGCCCCGCGACTGGCCGGCGCCC
GCGCGAGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References