65643

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2609924..2610518 Replicon chromosome
Accession NZ_CP016949
Organism Cupriavidus taiwanensis strain SWF66294

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag A9P79_RS11645 Protein ID WP_240071309.1
Coordinates 2610336..2610518 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag A9P79_RS11640 Protein ID WP_240071308.1
Coordinates 2609924..2610313 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9P79_RS11615 (A9P79_11430) 2605100..2605831 + 732 WP_115699262.1 3-oxoacyl-ACP reductase FabG -
A9P79_RS11620 (A9P79_11435) 2605863..2606768 - 906 WP_240071304.1 LysR family transcriptional regulator -
A9P79_RS11625 (A9P79_11440) 2606902..2608209 + 1308 WP_240071306.1 SGNH/GDSL hydrolase family protein -
A9P79_RS11630 (A9P79_11445) 2608167..2608820 - 654 WP_115699265.1 glutathione S-transferase family protein -
A9P79_RS11635 (A9P79_11450) 2608875..2609831 - 957 WP_240071307.1 prolyl aminopeptidase -
A9P79_RS11640 (A9P79_11455) 2609924..2610313 - 390 WP_240071308.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A9P79_RS11645 2610336..2610518 - 183 WP_240071309.1 type II toxin-antitoxin system HicA family toxin Toxin
A9P79_RS11650 (A9P79_11460) 2610598..2611485 - 888 WP_240071310.1 LysR substrate-binding domain-containing protein -
A9P79_RS11655 (A9P79_11465) 2611640..2612038 + 399 WP_115699269.1 RidA family protein -
A9P79_RS11660 (A9P79_11470) 2612035..2613165 + 1131 WP_240071311.1 NADH:flavin oxidoreductase -
A9P79_RS11665 (A9P79_11475) 2613178..2614176 - 999 WP_115702371.1 AraC family transcriptional regulator -
A9P79_RS11670 (A9P79_11480) 2614381..2615361 + 981 WP_115699271.1 quinone oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-122)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6753.97 Da        Isoelectric Point: 11.5016

>T65643 WP_240071309.1 NZ_CP016949:c2610518-2610336 [Cupriavidus taiwanensis]
MKSADLIRKLASDGWYLTNIVGSHHQFKHPSKPGKVTVPHPKKDLPLGTVRSILKQARIR

Download         Length: 183 bp

>T65643 NZ_CP016949:c2610518-2610336 [Cupriavidus taiwanensis]
ATGAAGAGCGCGGATCTGATCAGGAAACTGGCATCCGACGGCTGGTACTTGACGAATATCGTGGGGTCCCACCACCAGTT
CAAGCATCCATCCAAGCCCGGCAAAGTCACGGTGCCGCATCCGAAAAAAGACCTGCCCCTGGGCACAGTGCGCAGCATCC
TAAAACAGGCCCGCATCCGCTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14131.82 Da        Isoelectric Point: 4.5895

>AT65643 WP_240071308.1 NZ_CP016949:c2610313-2609924 [Cupriavidus taiwanensis]
MLYPVHIEPGDATHAHGVSFPDFPGCFSAADEWADIPANAQEAVEAHFGDGEAIPAPSAVERWLNDPDYQGGVWMLIDID
LSRVNTKAVRVNISLPERLVHAIDDAAKSRHMTRSAFLALAAQHEMDCR

Download         Length: 390 bp

>AT65643 NZ_CP016949:c2610313-2609924 [Cupriavidus taiwanensis]
ATGCTATATCCCGTTCACATCGAGCCGGGCGACGCAACCCACGCGCACGGCGTCTCGTTTCCGGACTTCCCCGGCTGTTT
TTCTGCAGCCGATGAGTGGGCCGACATTCCTGCCAATGCACAGGAAGCCGTTGAGGCGCACTTCGGCGATGGCGAAGCCA
TTCCCGCGCCGTCAGCCGTAGAGCGATGGTTGAACGATCCCGACTATCAAGGCGGTGTCTGGATGCTGATCGATATCGAT
CTGTCCCGCGTCAATACCAAGGCAGTGCGCGTAAACATCAGCCTGCCGGAGCGGCTGGTGCACGCCATCGACGACGCGGC
AAAGAGCAGGCATATGACGCGGTCCGCGTTTCTTGCTCTGGCGGCCCAGCACGAGATGGACTGCCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References