65642

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2244456..2245105 Replicon chromosome
Accession NZ_CP016949
Organism Cupriavidus taiwanensis strain SWF66294

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag A9P79_RS09980 Protein ID WP_240071089.1
Coordinates 2244456..2244863 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag A9P79_RS09985 Protein ID WP_240071090.1
Coordinates 2244863..2245105 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9P79_RS09965 (A9P79_09800) 2239699..2240172 + 474 WP_240071086.1 DM13 domain-containing protein -
A9P79_RS09970 (A9P79_09805) 2240366..2241433 - 1068 WP_240071087.1 porin -
A9P79_RS09975 (A9P79_09810) 2241767..2244406 + 2640 WP_240071088.1 transglycosylase domain-containing protein -
A9P79_RS09980 (A9P79_09815) 2244456..2244863 - 408 WP_240071089.1 type II toxin-antitoxin system VapC family toxin Toxin
A9P79_RS09985 (A9P79_09820) 2244863..2245105 - 243 WP_240071090.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
A9P79_RS09990 (A9P79_09825) 2245233..2246564 - 1332 WP_240071091.1 DUF1501 domain-containing protein -
A9P79_RS09995 (A9P79_09830) 2246582..2248186 - 1605 WP_240071092.1 DUF1800 domain-containing protein -
A9P79_RS10000 (A9P79_09835) 2248384..2249307 + 924 WP_240071093.1 EamA family transporter -
A9P79_RS10005 (A9P79_09840) 2249291..2250055 + 765 WP_240071094.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin

SpoVT-AbrB domain

(13-48)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14083.15 Da        Isoelectric Point: 4.8483

>T65642 WP_240071089.1 NZ_CP016949:c2244863-2244456 [Cupriavidus taiwanensis]
MTSFLLDTNIISDAIRNTRGACAARIASIEPDSLCTSIIVAAELRFGAAKKGSAALSERVSEALAGLRVLPLDGDADVRY
GSLRAALESSGGVIGANDMLIAAHALSLDAVLVTDNIGEFARVKGLRCENWLNPI

Download         Length: 408 bp

>T65642 NZ_CP016949:c2244863-2244456 [Cupriavidus taiwanensis]
ATGACGTCGTTTCTGCTCGATACCAACATTATTTCGGACGCCATCCGCAATACGCGCGGTGCCTGCGCCGCGCGGATCGC
TTCGATCGAGCCCGATAGCTTGTGCACTTCCATCATCGTGGCGGCTGAACTCCGCTTCGGCGCCGCCAAGAAGGGCTCCG
CAGCGCTGAGCGAACGTGTCAGCGAGGCCCTGGCGGGACTGCGGGTGTTGCCGCTGGACGGCGATGCCGATGTTCGCTAT
GGCAGCTTACGCGCTGCCTTGGAAAGCAGCGGCGGGGTGATTGGAGCCAATGACATGCTGATTGCCGCGCACGCTCTGTC
ACTCGATGCCGTGCTGGTAACCGACAACATTGGGGAATTTGCGCGCGTGAAGGGATTGCGCTGTGAAAACTGGCTGAATC
CCATATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9293.55 Da        Isoelectric Point: 4.2904

>AT65642 WP_240071090.1 NZ_CP016949:c2245105-2244863 [Cupriavidus taiwanensis]
MAQTDEIRHVRLFRNGRNQAIRIPREFELPGEEAILRREGDHLIIEPVASMPLRALLAQWEPIDVDWPEIDNLPADDVDL

Download         Length: 243 bp

>AT65642 NZ_CP016949:c2245105-2244863 [Cupriavidus taiwanensis]
ATGGCTCAGACTGACGAAATCCGCCATGTAAGACTGTTCCGCAATGGCCGCAACCAGGCGATTCGCATTCCGCGTGAGTT
CGAGTTGCCGGGCGAAGAGGCCATCTTGCGTCGTGAAGGCGACCATCTAATCATCGAGCCGGTTGCGTCGATGCCATTGC
GAGCCCTGCTGGCGCAATGGGAACCTATCGATGTGGATTGGCCAGAGATCGATAACCTGCCTGCAGATGATGTCGATCTC
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References