Detailed information of TA system TA065639

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapB(antitoxin)
• Location: 1377834..1378417
• Replicon: chromosome
• Accession: NZ_CP016949
• Organism: Cupriavidus taiwanensis strain SWF66294

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: A9P79_RS06170
• Protein ID: WP_240070610.1
• Coordinates: 1377834..1378214 (-)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B3R9Z5
• Locus tag: A9P79_RS06175
• Protein ID: WP_012355939.1
• Coordinates: 1378211..1378417 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A9P79_RS06155 (A9P79_06030)	1373841..1375304	-	1464	WP_240070609.1	MFS transporter	-
A9P79_RS06160 (A9P79_06035)	1375455..1376822	-	1368	WP_115700350.1	MFS transporter	-
A9P79_RS06165 (A9P79_06040)	1376834..1377751	-	918	WP_115700352.1	aldo/keto reductase	-
A9P79_RS06170 (A9P79_06045)	1377834..1378214	-	381	WP_240070610.1	VapC toxin family PIN domain ribonuclease	Toxin
A9P79_RS06175 (A9P79_06050)	1378211..1378417	-	207	WP_012355939.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
A9P79_RS06180 (A9P79_06055)	1378624..1379985	-	1362	WP_025581515.1	GntP family permease	-
A9P79_RS06185 (A9P79_06060)	1380208..1380600	-	393	WP_012355941.1	RidA family protein	-
A9P79_RS06190 (A9P79_06065)	1380653..1382107	-	1455	WP_240070611.1	D-aminoacylase	-
A9P79_RS06195 (A9P79_06070)	1382110..1383015	-	906	WP_240070612.1	MurR/RpiR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-43)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 13707.98 Da
• Isoelectric Point: 7.2440

>T65639 WP_240070610.1 NZ_CP016949:c1378214-1377834 [Cupriavidus taiwanensis]
MNVLVDTSVWVGHFRQRNDALIRLMEADQVLTHPLVVAELACGTPPAPRAQTLGDIGLLQAARQATLAEVIALVEREQLY
GLGCGLVDVTLLASTLITPGARLWTLDQRLSALSVRFGVGYRPRLH

Nucleotide

• Length: 381 bp

>T65639 NZ_CP016949:c1378214-1377834 [Cupriavidus taiwanensis]
ATGAACGTGCTCGTCGACACCTCGGTGTGGGTGGGCCATTTCCGGCAGCGCAATGACGCCCTCATCCGCCTCATGGAGGC
GGACCAGGTGCTGACCCATCCCCTGGTCGTGGCCGAACTGGCCTGCGGCACGCCACCGGCGCCGCGGGCGCAGACGCTCG
GCGACATCGGGTTGCTGCAGGCCGCCAGGCAGGCAACGCTGGCAGAAGTCATCGCGCTGGTGGAGCGCGAGCAACTGTAT
GGGCTGGGCTGCGGCCTGGTGGATGTCACCTTGCTGGCTTCGACCCTGATCACCCCCGGTGCCCGCCTCTGGACGCTGGA
CCAGCGCCTGAGCGCCTTGTCCGTCCGGTTTGGCGTGGGATATCGTCCTCGCCTGCACTAG

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7458.57 Da
• Isoelectric Point: 4.9987

>AT65639 WP_012355939.1 NZ_CP016949:c1378417-1378211 [Cupriavidus taiwanensis]
MRTTVTIDDALYEQALEMADPGMDKADLFREAIKTFVRVQAAKRLAALGGAAPGMQDVPRRNPEPDVK

Nucleotide

• Length: 207 bp

>AT65639 NZ_CP016949:c1378417-1378211 [Cupriavidus taiwanensis]
ATGCGCACGACAGTCACGATCGATGACGCTCTGTATGAACAAGCACTGGAGATGGCGGACCCCGGCATGGACAAGGCAGA
CCTGTTTCGCGAGGCAATCAAGACATTCGTTCGGGTGCAGGCCGCCAAGCGCCTCGCGGCCCTCGGCGGCGCAGCGCCCG
GCATGCAGGACGTACCGCGCCGCAATCCCGAACCCGACGTCAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A375HSQ8