Detailed information of TA system TA065636

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4553317..4554007
• Replicon: chromosome
• Accession: NZ_CP016948
• Organism: Serratia surfactantfaciens strain YD25

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: ATE40_RS21280
• Protein ID: WP_063918235.1
• Coordinates: 4553687..4554007 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: ATE40_RS24420
• Protein ID: WP_063918236.1
• Coordinates: 4553317..4553649 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ATE40_RS21245	4549096..4549824	+	729	WP_063918243.1	DUF3944 domain-containing protein	-
ATE40_RS21250	4549885..4550562	+	678	WP_063918242.1	WYL domain-containing protein	-
ATE40_RS21255	4550619..4551083	+	465	WP_063918241.1	hypothetical protein	-
ATE40_RS21260	4551170..4551529	+	360	WP_063918240.1	hypothetical protein	-
ATE40_RS21265	4551611..4551823	+	213	WP_063918239.1	hypothetical protein	-
ATE40_RS21270	4551924..4552742	+	819	WP_063918238.1	DUF945 domain-containing protein	-
ATE40_RS21275	4552813..4553286	+	474	WP_063918237.1	DNA repair protein RadC	-
ATE40_RS24420	4553317..4553649	+	333	WP_063918236.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
ATE40_RS21280	4553687..4554007	+	321	WP_063918235.1	TA system toxin CbtA family protein	Toxin
ATE40_RS21285	4554121..4554984	+	864	WP_063918234.1	DUF4942 domain-containing protein	-
ATE40_RS21290	4555187..4556089	-	903	WP_063918233.1	LysR family transcriptional regulator	-
ATE40_RS21295	4556230..4557765	+	1536	WP_063918232.1	MFS transporter	-
ATE40_RS21300	4557807..4558847	+	1041	WP_019452604.1	HlyD family secretion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4526847..4554984	28137

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (12-105)

Antitoxin

• Antitoxin CbeA (7-106)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12030.66 Da
• Isoelectric Point: 5.9580

>T65636 WP_063918235.1 NZ_CP016948:4553687-4554007 [Serratia surfactantfaciens]
MHISSVPASVPVASRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHEDAAIQEHIEAGITLADAVNFLVERYELVRTDRKGF
TWQEQTPFLTATDILRARRATGLMNT

Nucleotide

• Length: 321 bp

>T65636 NZ_CP016948:4553687-4554007 [Serratia surfactantfaciens]
ATGCACATTTCATCTGTACCGGCCTCGGTGCCGGTTGCGTCACGCCTGTCGCCCGTACAGGTCTGGCAGCAACTGTTAAC
GTATCTGCTGGAACATCATTACGGTCTGACGCTTAACGATACTCCTTTCCATGAAGATGCGGCCATCCAGGAGCATATTG
AAGCTGGCATTACACTTGCTGATGCGGTGAATTTCCTGGTGGAACGCTATGAATTGGTACGCACTGACCGCAAGGGGTTT
ACGTGGCAGGAGCAGACGCCATTCCTTACCGCTACCGATATTCTCAGAGCTAGGCGTGCCACCGGGCTGATGAATACGTA
A

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12199.63 Da
• Isoelectric Point: 6.0525

>AT65636 WP_063918236.1 NZ_CP016948:4553317-4553649 [Serratia surfactantfaciens]
MSLTPSHEWGLQSNITPRFGARLVQEGNRLHYLADRASLNGSFTPEQLQGLDQAFPLFIEQLETMLSSGELNPHQQHQVT
SQLAGLTCIADTRGSYGYVYIAIYSQSATK

Nucleotide

• Length: 333 bp

>AT65636 NZ_CP016948:4553317-4553649 [Serratia surfactantfaciens]
ATGTCATTAACACCATCCCATGAATGGGGACTACAAAGCAATATCACCCCACGGTTTGGCGCAAGGCTGGTTCAGGAGGG
TAATCGCCTACATTACTTGGCTGACAGGGCCAGTTTGAATGGGAGTTTTACACCAGAACAGCTTCAGGGGCTGGATCAGG
CTTTCCCGCTATTTATAGAGCAACTGGAAACTATGCTCAGCTCCGGTGAGCTAAATCCACACCAGCAACATCAAGTAACC
AGCCAGCTTGCGGGTTTGACCTGCATAGCTGATACCCGTGGTAGTTACGGCTACGTTTACATTGCTATTTATTCTCAGTC
AGCTACCAAGTAA