Detailed information of TA system TA065634

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3558222..3558891
• Replicon: chromosome
• Accession: NZ_CP016948
• Organism: Serratia surfactantfaciens strain YD25

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: ATE40_RS16730
• Protein ID: WP_019455658.1
• Coordinates: 3558222..3558644 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8B4GS04
• Locus tag: ATE40_RS16735
• Protein ID: WP_019455657.1
• Coordinates: 3558625..3558891 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ATE40_RS16710	3554112..3554630	+	519	WP_019455662.1	flavodoxin FldB	-
ATE40_RS16715	3554667..3556031	-	1365	WP_019455661.1	cell envelope integrity protein CreD	-
ATE40_RS16720	3556112..3557530	-	1419	WP_063917968.1	two-component system sensor histidine kinase CreC	-
ATE40_RS16725	3557527..3558222	-	696	WP_019455659.1	two-component system response regulator CreB	-
ATE40_RS16730	3558222..3558644	-	423	WP_019455658.1	protein YgfX	Toxin
ATE40_RS16735	3558625..3558891	-	267	WP_019455657.1	FAD assembly factor SdhE	Antitoxin
ATE40_RS16740	3559213..3560205	+	993	WP_063917969.1	tRNA-modifying protein YgfZ	-
ATE40_RS16745	3560244..3560741	-	498	WP_063917970.1	DUF2165 domain-containing protein	-
ATE40_RS16750	3560892..3561566	-	675	WP_063917971.1	hemolysin III family protein	-
ATE40_RS16755	3561750..3562358	+	609	WP_025304127.1	HD domain-containing protein	-
ATE40_RS16760	3562399..3563325	-	927	WP_019455653.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16510.58 Da
• Isoelectric Point: 10.6021

>T65634 WP_019455658.1 NZ_CP016948:c3558644-3558222 [Serratia surfactantfaciens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWQLAKKPWMPGYGMLLTLQPMEGKKRRRLWLASDCMGKEEWRHLRQLLLYPPAGDGEEH

Nucleotide

• Length: 423 bp

>T65634 NZ_CP016948:c3558644-3558222 [Serratia surfactantfaciens]
GTGGCCCAGTGGCGATGTGATATCCGTATTTCCTGGCGCACCCAGCTGTTTTCCCTGTTGACCCACGGGGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTTTGGCCCGCTCTGGCTGGTGTTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCGGCGGTGCAGGGTGAACTGCGGCTGCTGGCAGACCGGCGCTTCAGCTGGCACGGCCGC
GAATGGCAGCTGGCGAAAAAACCCTGGATGCCGGGCTACGGCATGCTGTTGACGCTGCAGCCGATGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGGGCAAGGAGGAGTGGCGCCATCTGCGGCAGCTGTTGCTGTATCCTCCGG
CGGGTGACGGCGAGGAGCACTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10417.91 Da
• Isoelectric Point: 4.7921

>AT65634 WP_019455657.1 NZ_CP016948:c3558891-3558625 [Serratia surfactantfaciens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT65634 NZ_CP016948:c3558891-3558625 [Serratia surfactantfaciens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGTTGTTCATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACAGCGAGCTGCAAAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GS04