Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3183521..3184177 Replicon chromosome
Accession NZ_CP016948
Organism Serratia surfactantfaciens strain YD25

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ATE40_RS14970 Protein ID WP_025159565.1
Coordinates 3183521..3183910 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ATE40_RS14975 Protein ID WP_019452401.1
Coordinates 3183914..3184177 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATE40_RS14955 3179988..3181418 + 1431 WP_019452405.1 multidrug transporter subunit MdtD -
ATE40_RS14960 3181415..3182797 + 1383 WP_019452404.1 two-component system sensor histidine kinase BaeS -
ATE40_RS14965 3182797..3183513 + 717 WP_019452403.1 two-component system response regulator BaeR -
ATE40_RS14970 3183521..3183910 - 390 WP_025159565.1 type II toxin-antitoxin system VapC family toxin Toxin
ATE40_RS14975 3183914..3184177 - 264 WP_019452401.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ATE40_RS14980 3184516..3184854 + 339 WP_033644064.1 YegP family protein -
ATE40_RS14985 3185034..3186386 + 1353 WP_025159564.1 tRNA 5-hydroxyuridine modification protein YegQ -
ATE40_RS14990 3186854..3187759 + 906 WP_019452397.1 lipid kinase YegS -
ATE40_RS14995 3188032..3189081 + 1050 WP_019452396.1 class I fructose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14355.61 Da        Isoelectric Point: 7.8794

>T65632 WP_025159565.1 NZ_CP016948:c3183910-3183521 [Serratia surfactantfaciens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFIAAVTVYAWDSEAARCYGEM
RANMERKGKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T65632 NZ_CP016948:c3183910-3183521 [Serratia surfactantfaciens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTATTGCCGCGGTAACGGTCTATGCATGGGATAGCGAGGCTGCCCGCTGTTACGGTGAAATG
CGGGCAAACATGGAGAGAAAGGGGAAAATCATGGGCGCGATGGATCAACTGATCGCCGCTCATGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGATTGGCTGTTGAGGACTGGACGCGCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10048.29 Da        Isoelectric Point: 4.6583

>AT65632 WP_019452401.1 NZ_CP016948:c3184177-3183914 [Serratia surfactantfaciens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEDE

Download         Length: 264 bp

>AT65632 NZ_CP016948:c3184177-3183914 [Serratia surfactantfaciens]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAGTTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCAGCAAAGCCGGACAGCTGGGCGCCGC
TGCTGAGCATTATCGCCCAAACGCCTGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCATTCTCAGAGGACGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References