Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3095830..3096392 Replicon chromosome
Accession NZ_CP016948
Organism Serratia surfactantfaciens strain YD25

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag ATE40_RS14565 Protein ID WP_019453865.1
Coordinates 3095830..3096186 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag ATE40_RS14570 Protein ID WP_004936539.1
Coordinates 3096183..3096392 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATE40_RS14545 3091566..3092363 - 798 WP_019453862.1 energy transducer TonB -
ATE40_RS14550 3092466..3093305 - 840 WP_063919835.1 ChaN family lipoprotein -
ATE40_RS14555 3093483..3094892 + 1410 WP_015378686.1 S-methylmethionine permease -
ATE40_RS14560 3094882..3095820 + 939 WP_063919836.1 homocysteine S-methyltransferase -
ATE40_RS14565 3095830..3096186 - 357 WP_019453865.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
ATE40_RS14570 3096183..3096392 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
ATE40_RS14575 3096502..3098781 - 2280 WP_016926766.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
ATE40_RS24895 3098997..3099170 - 174 WP_172837464.1 hypothetical protein -
ATE40_RS14580 3099151..3099531 - 381 WP_063919837.1 DUF2570 family protein -
ATE40_RS14585 3099528..3099929 - 402 WP_063919838.1 M15 family metallopeptidase -
ATE40_RS14590 3099919..3100245 - 327 WP_063919839.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(27-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13139.90 Da        Isoelectric Point: 4.8784

>T65631 WP_019453865.1 NZ_CP016948:c3096186-3095830 [Serratia surfactantfaciens]
MIFLTAEDIAEFNAEIVPHGRQDGSKVEAVANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAQLVELTVEAAQGRLNVEQAAEQLRRLTE

Download         Length: 357 bp

>T65631 NZ_CP016948:c3096186-3095830 [Serratia surfactantfaciens]
ATGATCTTTTTGACCGCAGAGGATATTGCGGAATTCAATGCTGAAATTGTGCCTCACGGCCGCCAGGATGGCAGTAAAGT
TGAGGCCGTAGCCAACCGCGTGCTCAATGCTTACCACTATGAGAACGTCACCGACGTTTACCGTTTGGCCGCACTTTATC
TCATTGCTATCAGTCATGGTCATATTTTTCTTGATGGCAATAAGCGCACGGCCTTCCAAAGCATGGCGTTATTTCTCGGT
ATCAATGGCATTGCACTGCGTGAAGATGCGCAGCTGGTTGAACTCACGGTCGAGGCTGCTCAAGGCCGCCTCAACGTCGA
ACAAGCCGCGGAGCAACTGCGCCGGTTAACCGAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT65631 WP_004936539.1 NZ_CP016948:c3096392-3096183 [Serratia surfactantfaciens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT65631 NZ_CP016948:c3096392-3096183 [Serratia surfactantfaciens]
ATGACTACGATTAGCTACACGGCGGCCAGAAACAACCTTGCCGAGGTGCTTTTGGAAGCGCAAAAACAGCCGGTGGAAGT
GACGCGCCGCGGACACGATGAGGTTTACATCATCAGTAAGGCAGACTATGAGGTTTTGGTCAAAGCCAAGGTGAAAGCGC
GCATTCAGGCTAAACACGCGGATACGATTAAGGCGCTGGCCAATAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References