Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2429829..2430460 Replicon chromosome
Accession NZ_CP016948
Organism Serratia surfactantfaciens strain YD25

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ATE40_RS11475 Protein ID WP_063918547.1
Coordinates 2429829..2430227 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ATE40_RS11480 Protein ID WP_063918548.1
Coordinates 2430227..2430460 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATE40_RS11450 2425400..2425771 + 372 WP_063918546.1 type II toxin-antitoxin system RelE/ParE family toxin -
ATE40_RS11455 2425768..2426070 + 303 WP_033632742.1 DNA-binding transcriptional regulator -
ATE40_RS11460 2426073..2426477 - 405 WP_019452960.1 flagellar protein FlhE -
ATE40_RS11465 2426477..2428555 - 2079 WP_019452961.1 flagellar biosynthesis protein FlhA -
ATE40_RS11470 2428548..2429699 - 1152 WP_019452962.1 flagellar type III secretion system protein FlhB -
ATE40_RS11475 2429829..2430227 - 399 WP_063918547.1 type II toxin-antitoxin system VapC family toxin Toxin
ATE40_RS11480 2430227..2430460 - 234 WP_063918548.1 antitoxin Antitoxin
ATE40_RS11485 2430586..2431230 - 645 WP_004934858.1 protein phosphatase CheZ -
ATE40_RS11490 2431241..2431630 - 390 WP_004934862.1 chemotaxis response regulator CheY -
ATE40_RS11495 2431733..2432782 - 1050 WP_016927288.1 chemotaxis response regulator protein-glutamate methylesterase -
ATE40_RS11500 2432782..2433654 - 873 WP_025159837.1 protein-glutamate O-methyltransferase CheR -
ATE40_RS11505 2433683..2435308 - 1626 WP_019452966.1 Tar ligand binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14911.07 Da        Isoelectric Point: 8.4598

>T65629 WP_063918547.1 NZ_CP016948:c2430227-2429829 [Serratia surfactantfaciens]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSVTYGELVHGVEKSSRPAVNARVVEDFVSRLDILDYGAKAASHY
GNIRAALERHGTPIGVNDLYIAGHARSEGLILVTNNRREFERVDGLRLENWL

Download         Length: 399 bp

>T65629 NZ_CP016948:c2430227-2429829 [Serratia surfactantfaciens]
ATGTTCAGCCATATGCTGGACACCAATATTGTTATCTATGTCATCAAGCGCCGGCCTCTGGAAGTGCTGGAGGCGTTCAA
TCGCTATGCGGGCAAAATGGTCATTTCGTCGGTCACCTATGGCGAATTGGTTCACGGAGTGGAGAAAAGCTCGCGTCCGG
CGGTTAACGCCAGAGTGGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACGGCGCCAAAGCGGCTTCGCACTAC
GGCAACATTCGGGCTGCGCTGGAACGTCATGGAACGCCTATTGGCGTAAACGATCTGTATATCGCCGGGCATGCGCGCAG
CGAAGGATTGATTCTGGTGACCAATAACCGACGCGAATTTGAGCGCGTTGATGGCTTACGGCTGGAAAATTGGCTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8870.94 Da        Isoelectric Point: 5.8291

>AT65629 WP_063918548.1 NZ_CP016948:c2430460-2430227 [Serratia surfactantfaciens]
MTLGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPVENTWDSFFCAKNEVSDDFLNERAGQHQREREEF

Download         Length: 234 bp

>AT65629 NZ_CP016948:c2430460-2430227 [Serratia surfactantfaciens]
ATGACGTTAGGTTCTGTCTTTACCAATAATCGGACGCAGGCCGTGCGCTTGCCTGCAGAGGTGCGTTTCCCCGATACCGT
TTCTAAAGTGACCGTCCGCGTGGTGGGCAAAGAGCGCATTCTTGCGCCGGTGGAGAATACCTGGGACAGTTTCTTCTGCG
CGAAAAATGAGGTGAGCGATGACTTCCTCAATGAACGTGCCGGGCAACACCAGCGTGAGCGGGAAGAGTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References