Detailed information of TA system TA065628

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2387486..2388115
• Replicon: chromosome
• Accession: NZ_CP016948
• Organism: Serratia surfactantfaciens strain YD25

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: ATE40_RS11225
• Protein ID: WP_063918536.1
• Coordinates: 2387486..2387689 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: ATE40_RS11230
• Protein ID: WP_019452924.1
• Coordinates: 2387702..2388115 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ATE40_RS11220	2383351..2387322	+	3972	WP_063918535.1	trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase	-
ATE40_RS11225	2387486..2387689	+	204	WP_063918536.1	type II toxin-antitoxin system HicA family toxin	Toxin
ATE40_RS11230	2387702..2388115	+	414	WP_019452924.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ATE40_RS11235	2388145..2388897	-	753	WP_063918537.1	L-cystine ABC transporter ATP-binding protein YecC	-
ATE40_RS11240	2388901..2389563	-	663	WP_025303237.1	cystine ABC transporter permease	-
ATE40_RS11245	2389563..2390363	-	801	WP_019452927.1	cystine ABC transporter substrate-binding protein	-
ATE40_RS11250	2390479..2391471	-	993	WP_019452928.1	D-cysteine desulfhydrase	-
ATE40_RS11255	2391597..2392106	-	510	WP_025159834.1	flagella biosynthesis regulatory protein FliZ	-
ATE40_RS11260	2392163..2392885	-	723	WP_004934752.1	RNA polymerase sigma factor FliA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	fliZ / fliA / fliS	2373918..2399186	25268

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7523.85 Da
• Isoelectric Point: 11.0566

>T65628 WP_063918536.1 NZ_CP016948:2387486-2387689 [Serratia surfactantfaciens]
VKSSELIALLESHGWVLRRVKGSHHQFKHPDFALIITVPHPNKDLKLGTLRQILKDAGLTALHIATR

Nucleotide

• Length: 204 bp

>T65628 NZ_CP016948:2387486-2387689 [Serratia surfactantfaciens]
GTGAAGAGTTCAGAGCTGATCGCGCTGCTGGAAAGCCACGGCTGGGTATTGCGGCGGGTAAAAGGCAGCCACCATCAATT
CAAACATCCCGATTTTGCGCTGATCATCACCGTGCCGCACCCAAACAAAGATCTCAAGCTGGGCACGCTGCGGCAGATAC
TTAAAGACGCGGGGTTAACTGCACTTCACATCGCCACGCGTTAG

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15019.84 Da
• Isoelectric Point: 5.1486

>AT65628 WP_019452924.1 NZ_CP016948:2387702-2388115 [Serratia surfactantfaciens]
MFYPAYIHTESDGSASGFFPDVPGCYFAGASLDDAFADAQSALDAHFELLSEDNQPIPRPRAVAVHLAKNAESFEGGQWL
LIAINMDKFDGRAERINITLPHRLLSRIDSLVRQHPGYGSRSGFLAAAARNELLKVE

Nucleotide

• Length: 414 bp

>AT65628 NZ_CP016948:2387702-2388115 [Serratia surfactantfaciens]
ATGTTTTATCCCGCTTACATCCATACCGAATCAGACGGCAGCGCCAGCGGTTTCTTTCCCGATGTCCCCGGTTGTTATTT
CGCCGGCGCCAGCCTGGACGACGCCTTTGCCGATGCCCAAAGCGCGCTGGATGCGCACTTTGAGTTGTTGAGCGAAGACA
ATCAGCCGATACCGCGTCCGCGGGCCGTCGCCGTGCATCTTGCCAAAAACGCGGAATCCTTCGAGGGGGGGCAGTGGCTG
TTGATCGCTATCAATATGGATAAGTTTGACGGCCGGGCCGAGCGAATCAATATCACGCTGCCCCACCGACTGTTAAGCCG
CATTGATTCTCTGGTTCGGCAACATCCTGGATACGGCAGCCGCAGCGGGTTTCTCGCCGCCGCCGCGCGAAATGAATTGT
TGAAAGTGGAGTGA