Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 925144..925697 Replicon chromosome
Accession NZ_CP016948
Organism Serratia surfactantfaciens strain YD25

Toxin (Protein)


Gene name ccdB Uniprot ID A0A2V4FZ31
Locus tag ATE40_RS04470 Protein ID WP_019454426.1
Coordinates 925383..925697 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2V4GJ62
Locus tag ATE40_RS04465 Protein ID WP_029988820.1
Coordinates 925144..925380 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATE40_RS04450 921611..923146 + 1536 WP_063919056.1 glutathione ABC transporter substrate-binding protein GsiB -
ATE40_RS04455 923199..924119 + 921 WP_019454429.1 glutathione ABC transporter permease GsiC -
ATE40_RS04460 924129..925037 + 909 WP_177342835.1 glutathione ABC transporter permease GsiD -
ATE40_RS04465 925144..925380 + 237 WP_029988820.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
ATE40_RS04470 925383..925697 + 315 WP_019454426.1 CcdB family protein Toxin
ATE40_RS04475 925733..926575 - 843 WP_019454425.1 S-formylglutathione hydrolase -
ATE40_RS04480 926590..927714 - 1125 WP_063919057.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
ATE40_RS04485 927745..928665 - 921 WP_063919058.1 LysR family transcriptional regulator -
ATE40_RS04490 928771..929928 + 1158 WP_063919593.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11745.68 Da        Isoelectric Point: 5.0488

>T65619 WP_019454426.1 NZ_CP016948:925383-925697 [Serratia surfactantfaciens]
MQFTVYANRGNSAVYPLLLDVTSDIIGQLNRRVVIPLLPVEKYPGSTRPERLIPLIRLIDDNEYAVMTYEMASIPVRALG
AEFCDVSQYRTRIKAAIDFLLDGI

Download         Length: 315 bp

>T65619 NZ_CP016948:925383-925697 [Serratia surfactantfaciens]
ATGCAATTTACGGTGTATGCGAATAGGGGGAACAGCGCGGTTTATCCCCTGCTGCTTGATGTGACGAGCGATATCATTGG
GCAATTAAATCGTCGGGTTGTGATCCCTTTGTTGCCCGTTGAAAAATACCCGGGGAGTACACGACCGGAGCGCTTGATCC
CGTTGATCAGATTGATTGATGACAACGAGTACGCCGTGATGACATATGAAATGGCCAGCATCCCGGTTCGGGCTTTGGGG
GCCGAGTTTTGTGATGTTTCCCAGTATCGGACCAGGATAAAAGCCGCCATCGACTTTCTTCTTGACGGTATTTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9082.13 Da        Isoelectric Point: 5.7070

>AT65619 WP_029988820.1 NZ_CP016948:925144-925380 [Serratia surfactantfaciens]
MPVKQRTTQSVTMTLERSLLSRAREAGINLSATLTAALDAELRQHERIKWQEENREALEALNRFNDEHGCFSDEYRTF

Download         Length: 237 bp

>AT65619 NZ_CP016948:925144-925380 [Serratia surfactantfaciens]
ATGCCAGTAAAACAACGAACGACGCAAAGTGTGACCATGACGCTGGAACGCAGTTTGTTGAGCCGTGCGCGTGAGGCGGG
GATTAATCTCAGTGCGACGCTAACTGCTGCTTTAGATGCTGAGTTGCGTCAGCATGAGAGGATAAAATGGCAGGAAGAAA
ACCGAGAGGCGCTTGAAGCGCTTAACCGATTTAATGATGAGCATGGTTGCTTTAGCGACGAATACAGGACGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V4FZ31

Antitoxin

Source ID Structure
AlphaFold DB A0A2V4GJ62

References