Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 423612..424234 | Replicon | chromosome |
Accession | NZ_CP016948 | ||
Organism | Serratia surfactantfaciens strain YD25 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | A0A8B4G7F9 |
Locus tag | ATE40_RS01990 | Protein ID | WP_004940313.1 |
Coordinates | 423612..423815 (-) | Length | 68 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | A0A2X2G5J9 |
Locus tag | ATE40_RS01995 | Protein ID | WP_004940312.1 |
Coordinates | 423866..424234 (-) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ATE40_RS01960 | 419314..419652 | + | 339 | WP_004940327.1 | P-II family nitrogen regulator | - |
ATE40_RS01965 | 419689..420975 | + | 1287 | WP_063918847.1 | ammonium transporter AmtB | - |
ATE40_RS01970 | 421071..421934 | - | 864 | WP_063918848.1 | acyl-CoA thioesterase II | - |
ATE40_RS01975 | 422166..422657 | + | 492 | WP_004940318.1 | YbaY family lipoprotein | - |
ATE40_RS01980 | 422722..423036 | - | 315 | WP_019454177.1 | MGMT family protein | - |
ATE40_RS01990 | 423612..423815 | - | 204 | WP_004940313.1 | hemolysin expression modulator Hha | Toxin |
ATE40_RS01995 | 423866..424234 | - | 369 | WP_004940312.1 | Hha toxicity modulator TomB | Antitoxin |
ATE40_RS02000 | 424393..424746 | - | 354 | WP_019454176.1 | hypothetical protein | - |
ATE40_RS02005 | 425153..425866 | + | 714 | WP_063918849.1 | ABC transporter ATP-binding protein | - |
ATE40_RS02010 | 425863..426720 | + | 858 | WP_019454174.1 | metal ABC transporter permease | - |
ATE40_RS02015 | 426746..427624 | + | 879 | WP_019454173.1 | metal ABC transporter substrate-binding protein | - |
ATE40_RS02020 | 427731..427871 | - | 141 | WP_004940304.1 | type B 50S ribosomal protein L36 | - |
ATE40_RS02025 | 427884..428138 | - | 255 | WP_004940303.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 68 a.a. Molecular weight: 8107.37 Da Isoelectric Point: 6.9756
>T65618 WP_004940313.1 NZ_CP016948:c423815-423612 [Serratia surfactantfaciens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR
Download Length: 204 bp
>T65618 NZ_CP016948:c423815-423612 [Serratia surfactantfaciens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATCGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCCGCCGATCACCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATCGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCCGCCGATCACCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 14261.95 Da Isoelectric Point: 4.4314
>AT65618 WP_004940312.1 NZ_CP016948:c424234-423866 [Serratia surfactantfaciens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT
Download Length: 369 bp
>AT65618 NZ_CP016948:c424234-423866 [Serratia surfactantfaciens]
ATGGATGAGTATTCGCCTAAGCGACACGATATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
CACCCTGGGAGACAGTCACCATGGCTGGGTTAACGATCCGACATCTTCCGTCAACCTGCAGCTGAATGAGTTGATTGAAC
ATATCGCTTCGTTTGTGATGAGCTATAAAATTAAATACATGGACGAATCCGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGTTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGTTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG
ATGGATGAGTATTCGCCTAAGCGACACGATATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
CACCCTGGGAGACAGTCACCATGGCTGGGTTAACGATCCGACATCTTCCGTCAACCTGCAGCTGAATGAGTTGATTGAAC
ATATCGCTTCGTTTGTGATGAGCTATAAAATTAAATACATGGACGAATCCGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGTTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGTTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A8B4G7F9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2X2G5J9 |