Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 423612..424234 Replicon chromosome
Accession NZ_CP016948
Organism Serratia surfactantfaciens strain YD25

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag ATE40_RS01990 Protein ID WP_004940313.1
Coordinates 423612..423815 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag ATE40_RS01995 Protein ID WP_004940312.1
Coordinates 423866..424234 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATE40_RS01960 419314..419652 + 339 WP_004940327.1 P-II family nitrogen regulator -
ATE40_RS01965 419689..420975 + 1287 WP_063918847.1 ammonium transporter AmtB -
ATE40_RS01970 421071..421934 - 864 WP_063918848.1 acyl-CoA thioesterase II -
ATE40_RS01975 422166..422657 + 492 WP_004940318.1 YbaY family lipoprotein -
ATE40_RS01980 422722..423036 - 315 WP_019454177.1 MGMT family protein -
ATE40_RS01990 423612..423815 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
ATE40_RS01995 423866..424234 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
ATE40_RS02000 424393..424746 - 354 WP_019454176.1 hypothetical protein -
ATE40_RS02005 425153..425866 + 714 WP_063918849.1 ABC transporter ATP-binding protein -
ATE40_RS02010 425863..426720 + 858 WP_019454174.1 metal ABC transporter permease -
ATE40_RS02015 426746..427624 + 879 WP_019454173.1 metal ABC transporter substrate-binding protein -
ATE40_RS02020 427731..427871 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
ATE40_RS02025 427884..428138 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-64)

Antitoxin

(1-118)


Sequences


Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T65618 WP_004940313.1 NZ_CP016948:c423815-423612 [Serratia surfactantfaciens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T65618 NZ_CP016948:c423815-423612 [Serratia surfactantfaciens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATCGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCCGCCGATCACCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT65618 WP_004940312.1 NZ_CP016948:c424234-423866 [Serratia surfactantfaciens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT65618 NZ_CP016948:c424234-423866 [Serratia surfactantfaciens]
ATGGATGAGTATTCGCCTAAGCGACACGATATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
CACCCTGGGAGACAGTCACCATGGCTGGGTTAACGATCCGACATCTTCCGTCAACCTGCAGCTGAATGAGTTGATTGAAC
ATATCGCTTCGTTTGTGATGAGCTATAAAATTAAATACATGGACGAATCCGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGTTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGTTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9


Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References