Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4462586..4463229 Replicon chromosome
Accession NZ_CP016945
Organism Yersinia enterocolitica strain YE1

Toxin (Protein)


Gene name vagD Uniprot ID A0A7U7IT36
Locus tag BFS78_RS20645 Protein ID WP_005161957.1
Coordinates 4462586..4463005 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A0E1NFG4
Locus tag BFS78_RS20650 Protein ID WP_005161959.1
Coordinates 4463002..4463229 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFS78_RS20625 4457805..4458659 + 855 WP_005178323.1 formate dehydrogenase accessory sulfurtransferase FdhD -
BFS78_RS20630 4458786..4459409 + 624 WP_013650637.1 superoxide dismutase [Mn] -
BFS78_RS20635 4459733..4461682 + 1950 WP_057618828.1 methyl-accepting chemotaxis protein -
BFS78_RS20640 4461761..4462432 + 672 WP_049525202.1 6-N-hydroxylaminopurine resistance protein -
BFS78_RS20645 4462586..4463005 - 420 WP_005161957.1 type II toxin-antitoxin system VapC family toxin Toxin
BFS78_RS20650 4463002..4463229 - 228 WP_005161959.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BFS78_RS20655 4463361..4463717 - 357 WP_005161962.1 YibL family ribosome-associated protein -
BFS78_RS20660 4463810..4465291 - 1482 WP_049525201.1 PLP-dependent aminotransferase family protein -
BFS78_RS20665 4465559..4466170 + 612 WP_013650641.1 LysE family translocator -
BFS78_RS20670 4466167..4466721 - 555 WP_020283571.1 MltR family transcriptional regulator -
BFS78_RS20675 4466952..4468115 - 1164 WP_013650643.1 mannitol-1-phosphate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-131)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15582.17 Da        Isoelectric Point: 9.0596

>T65616 WP_005161957.1 NZ_CP016945:c4463005-4462586 [Yersinia enterocolitica]
MIKKLYMLDTNICSFIMRERPAELIIKLQQCIEHQNKIVVSAITYSEMRFGAIGKKASPKHNYLVDEFVKRLDAILPWDT
AAVDATTNIKVELAKQGTPIGGNDAAIAGHAVSAGAILVTNNIREFERVKKLRIEDWTQ

Download         Length: 420 bp

>T65616 NZ_CP016945:c4463005-4462586 [Yersinia enterocolitica]
ATGATCAAAAAATTATATATGCTTGATACGAATATTTGTTCTTTTATTATGCGGGAACGACCAGCAGAATTAATTATAAA
ATTACAACAGTGTATTGAGCATCAGAATAAAATAGTTGTTTCAGCAATTACATACTCAGAAATGCGGTTTGGCGCTATAG
GTAAGAAAGCATCTCCAAAGCATAATTATTTAGTTGATGAATTTGTAAAAAGGTTAGATGCTATTTTACCGTGGGATACC
GCAGCTGTTGATGCCACGACTAATATTAAGGTTGAGCTGGCAAAGCAGGGGACACCAATTGGTGGAAATGATGCCGCAAT
AGCCGGGCACGCAGTTTCTGCTGGAGCAATATTAGTCACTAATAATATTAGAGAGTTTGAACGAGTTAAAAAACTACGAA
TTGAAGATTGGACTCAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8786.91 Da        Isoelectric Point: 4.1971

>AT65616 WP_005161959.1 NZ_CP016945:c4463229-4463002 [Yersinia enterocolitica]
MRTVSIFKNGQNRAIRLPKDMDFDGVTELEILRDGDSIILRPIRPTWVSFMDEDKADDDFLAERQDVIEEGRFEL

Download         Length: 228 bp

>AT65616 NZ_CP016945:c4463229-4463002 [Yersinia enterocolitica]
ATGAGAACGGTATCTATTTTCAAAAATGGGCAGAATCGAGCAATTCGTTTGCCAAAAGATATGGATTTTGATGGCGTGAC
CGAGCTGGAAATACTCAGAGACGGTGATAGTATTATTTTACGACCCATACGCCCGACATGGGTATCATTCATGGATGAAG
ATAAGGCAGATGATGATTTTCTTGCCGAAAGACAGGATGTTATCGAAGAAGGACGCTTCGAGTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IT36

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1NFG4

References