Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4047612..4048147 Replicon chromosome
Accession NZ_CP016945
Organism Yersinia enterocolitica strain YE1

Toxin (Protein)


Gene name relE Uniprot ID A0A7U7G363
Locus tag BFS78_RS18730 Protein ID WP_049528305.1
Coordinates 4047612..4047899 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U7FI63
Locus tag BFS78_RS18735 Protein ID WP_005156229.1
Coordinates 4047896..4048147 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFS78_RS18700 4042872..4043678 + 807 WP_049528299.1 phosphonate C-P lyase system protein PhnK -
BFS78_RS18705 4043692..4044426 + 735 WP_005156211.1 phosphonate C-P lyase system protein PhnL -
BFS78_RS18710 4044423..4045571 + 1149 WP_005156213.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
BFS78_RS18715 4045571..4046110 + 540 Protein_3674 ribose 1,5-bisphosphokinase -
BFS78_RS18720 4046139..4046906 + 768 WP_069009520.1 phosphonate metabolism protein PhnP -
BFS78_RS18725 4046907..4047536 - 630 WP_049529127.1 hypothetical protein -
BFS78_RS18730 4047612..4047899 - 288 WP_049528305.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BFS78_RS18735 4047896..4048147 - 252 WP_005156229.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BFS78_RS18740 4048355..4048807 - 453 WP_005181269.1 YhbP family protein -
BFS78_RS18745 4048881..4050047 - 1167 WP_069009524.1 alginate lyase family protein -
BFS78_RS18750 4050061..4051176 - 1116 WP_005156237.1 ABC transporter ATP-binding protein -
BFS78_RS18755 4051188..4052027 - 840 WP_005156238.1 carbohydrate ABC transporter permease -
BFS78_RS18760 4052046..4052930 - 885 WP_005156239.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11016.10 Da        Isoelectric Point: 10.3544

>T65614 WP_049528305.1 NZ_CP016945:c4047899-4047612 [Yersinia enterocolitica]
MIYKLKFRSDALKEWGKIDKVIQQQFAKKLKKCCENPHIPSAKLRGLSDCYKIKLRASGFRLVYQVIEDCLVIAVVAVGK
RERSDVYNLASERLR

Download         Length: 288 bp

>T65614 NZ_CP016945:c4047899-4047612 [Yersinia enterocolitica]
ATGATTTATAAATTAAAATTTAGAAGTGATGCCCTAAAGGAATGGGGAAAGATAGACAAAGTTATTCAACAGCAGTTTGC
TAAAAAACTCAAAAAATGTTGTGAAAATCCTCATATTCCATCAGCAAAATTACGCGGATTATCAGACTGCTATAAAATAA
AATTACGGGCATCTGGTTTTAGGTTAGTTTATCAAGTTATTGAAGATTGTTTAGTTATCGCCGTGGTTGCCGTCGGCAAA
CGCGAACGCAGTGATGTTTATAACCTCGCCAGTGAACGGTTACGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9270.65 Da        Isoelectric Point: 4.2264

>AT65614 WP_005156229.1 NZ_CP016945:c4048147-4047896 [Yersinia enterocolitica]
MANIILSDTSASVSELKKNPMATVKAGAGYPVAILNRNQPAFYCIPAELYERMLDALDDQELIRLVTERESQPLIDVDLD
KYL

Download         Length: 252 bp

>AT65614 NZ_CP016945:c4048147-4047896 [Yersinia enterocolitica]
ATGGCTAACATAATTTTAAGTGATACGAGCGCAAGTGTCAGCGAGTTAAAGAAAAACCCTATGGCCACAGTCAAAGCGGG
GGCGGGCTATCCAGTGGCTATTTTGAATAGAAACCAACCGGCATTTTATTGTATCCCCGCAGAATTATACGAGAGAATGC
TAGATGCCCTTGATGATCAAGAGCTTATCAGATTAGTTACCGAACGAGAGAGTCAGCCACTCATTGATGTAGATCTGGAT
AAGTATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7G363

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FI63

References