Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1247689..1248307 Replicon chromosome
Accession NZ_CP016945
Organism Yersinia enterocolitica strain YE1

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag BFS78_RS05725 Protein ID WP_002208622.1
Coordinates 1247689..1247892 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7U7FKE5
Locus tag BFS78_RS05730 Protein ID WP_005163463.1
Coordinates 1247939..1248307 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFS78_RS05695 1243060..1243398 + 339 WP_002208627.1 P-II family nitrogen regulator -
BFS78_RS05700 1243438..1244727 + 1290 WP_005167660.1 ammonium transporter AmtB -
BFS78_RS05705 1244841..1245704 - 864 WP_005163474.1 acyl-CoA thioesterase II -
BFS78_RS05710 1245965..1246495 + 531 WP_005163468.1 YbaY family lipoprotein -
BFS78_RS05715 1246547..1246852 - 306 WP_005163466.1 MGMT family protein -
BFS78_RS05725 1247689..1247892 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
BFS78_RS05730 1247939..1248307 - 369 WP_005163463.1 Hha toxicity modulator TomB Antitoxin
BFS78_RS05735 1248465..1248818 - 354 WP_005163460.1 hypothetical protein -
BFS78_RS05740 1249584..1250294 + 711 WP_013649453.1 ABC transporter ATP-binding protein -
BFS78_RS05745 1250308..1251165 + 858 WP_020283451.1 metal ABC transporter permease -
BFS78_RS05750 1251228..1252106 + 879 WP_049525734.1 metal ABC transporter substrate-binding protein -
BFS78_RS05755 1252234..1252377 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
BFS78_RS05760 1252393..1252653 - 261 WP_005163438.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T65602 WP_002208622.1 NZ_CP016945:c1247892-1247689 [Yersinia enterocolitica]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T65602 NZ_CP016945:c1247892-1247689 [Yersinia enterocolitica]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATTGATACATTGGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGACGATGAGCTGGAATTGTTTTACTCAGCAGCAGACCACCGCTTAGCTGAACTCACAATGAATAAAC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14192.90 Da        Isoelectric Point: 4.3377

>AT65602 WP_005163463.1 NZ_CP016945:c1248307-1247939 [Yersinia enterocolitica]
MDEYSPKRHDVAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDDGDLSELVEEYL
DDTYTLFSSYGINDPELQRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp

>AT65602 NZ_CP016945:c1248307-1247939 [Yersinia enterocolitica]
ATGGATGAGTACTCACCTAAGCGGCATGACGTTGCCCAATTGAAGTTCCTGTGCGAGAGTTTGTATGATGAAGGCATTGC
TACCCTTGGTGATAGCCATCATGGCTGGGTAAATGATCCAACTTCAGCCGTAAACCTGCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGACGGCGACCTTTCAGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTACGGAATCAATGATCCGGAATTGCAGCGCTGGCAAAAAACTAAAGAGCGTTT
ATTCAGACTTTTCTCAGGGGAATACATCTGTACCCTGATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
PDB 2MN2
AlphaFold DB A0A7U7FKE5

References