Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4044754..4045289 Replicon chromosome
Accession NZ_CP016944
Organism Yersinia enterocolitica strain YE3

Toxin (Protein)


Gene name relE Uniprot ID A0A7U7G363
Locus tag BED35_RS19645 Protein ID WP_049528305.1
Coordinates 4044754..4045041 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U7FI63
Locus tag BED35_RS19650 Protein ID WP_005156229.1
Coordinates 4045038..4045289 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BED35_RS19615 4040014..4040820 + 807 WP_049528299.1 phosphonate C-P lyase system protein PhnK -
BED35_RS19620 4040834..4041568 + 735 WP_005156211.1 phosphonate C-P lyase system protein PhnL -
BED35_RS19625 4041565..4042713 + 1149 WP_005156213.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
BED35_RS19630 4042713..4043252 + 540 Protein_3671 ribose 1,5-bisphosphokinase -
BED35_RS19635 4043281..4044048 + 768 WP_069009520.1 phosphonate metabolism protein PhnP -
BED35_RS19640 4044049..4044678 - 630 WP_049529127.1 hypothetical protein -
BED35_RS19645 4044754..4045041 - 288 WP_049528305.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BED35_RS19650 4045038..4045289 - 252 WP_005156229.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BED35_RS19655 4045497..4045949 - 453 WP_005181269.1 YhbP family protein -
BED35_RS19660 4046023..4047189 - 1167 WP_069009524.1 alginate lyase family protein -
BED35_RS19665 4047203..4048318 - 1116 WP_005156237.1 ABC transporter ATP-binding protein -
BED35_RS19670 4048330..4049169 - 840 WP_005156238.1 carbohydrate ABC transporter permease -
BED35_RS19675 4049188..4050072 - 885 WP_005156239.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11016.10 Da        Isoelectric Point: 10.3544

>T65596 WP_049528305.1 NZ_CP016944:c4045041-4044754 [Yersinia enterocolitica]
MIYKLKFRSDALKEWGKIDKVIQQQFAKKLKKCCENPHIPSAKLRGLSDCYKIKLRASGFRLVYQVIEDCLVIAVVAVGK
RERSDVYNLASERLR

Download         Length: 288 bp

>T65596 NZ_CP016944:c4045041-4044754 [Yersinia enterocolitica]
ATGATTTATAAATTAAAATTTAGAAGTGATGCCCTAAAGGAATGGGGAAAGATAGACAAAGTTATTCAACAGCAGTTTGC
TAAAAAACTCAAAAAATGTTGTGAAAATCCTCATATTCCATCAGCAAAATTACGCGGATTATCAGACTGCTATAAAATAA
AATTACGGGCATCTGGTTTTAGGTTAGTTTATCAAGTTATTGAAGATTGTTTAGTTATCGCCGTGGTTGCCGTCGGCAAA
CGCGAACGCAGTGATGTTTATAACCTCGCCAGTGAACGGTTACGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9270.65 Da        Isoelectric Point: 4.2264

>AT65596 WP_005156229.1 NZ_CP016944:c4045289-4045038 [Yersinia enterocolitica]
MANIILSDTSASVSELKKNPMATVKAGAGYPVAILNRNQPAFYCIPAELYERMLDALDDQELIRLVTERESQPLIDVDLD
KYL

Download         Length: 252 bp

>AT65596 NZ_CP016944:c4045289-4045038 [Yersinia enterocolitica]
ATGGCTAACATAATTTTAAGTGATACGAGCGCAAGTGTCAGCGAGTTAAAGAAAAACCCTATGGCCACAGTCAAAGCGGG
GGCGGGCTATCCAGTGGCTATTTTGAATAGAAACCAACCGGCATTTTATTGTATCCCCGCAGAATTATACGAGAGAATGC
TAGATGCCCTTGATGATCAAGAGCTTATCAGATTAGTTACCGAACGAGAGAGTCAGCCACTCATTGATGTAGATCTGGAT
AAGTATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7G363

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FI63

References