Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3712372..3713044 Replicon chromosome
Accession NZ_CP016944
Organism Yersinia enterocolitica strain YE3

Toxin (Protein)


Gene name cptA Uniprot ID A0A7U7FIQ4
Locus tag BED35_RS18300 Protein ID WP_005166047.1
Coordinates 3712372..3712797 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7U7FJE4
Locus tag BED35_RS18305 Protein ID WP_004390965.1
Coordinates 3712778..3713044 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BED35_RS18280 3708146..3708664 + 519 WP_005166042.1 flavodoxin FldB -
BED35_RS18285 3708723..3710144 - 1422 WP_049527976.1 cell envelope integrity protein CreD -
BED35_RS18290 3710236..3711663 - 1428 WP_049527980.1 two-component system sensor histidine kinase CreC -
BED35_RS18295 3711674..3712372 - 699 WP_005166045.1 two-component system response regulator CreB -
BED35_RS18300 3712372..3712797 - 426 WP_005166047.1 protein YgfX Toxin
BED35_RS18305 3712778..3713044 - 267 WP_004390965.1 FAD assembly factor SdhE Antitoxin
BED35_RS18310 3713311..3714303 + 993 WP_049527983.1 tRNA-modifying protein YgfZ -
BED35_RS18315 3714499..3715518 + 1020 WP_084738255.1 IS110 family transposase -
BED35_RS18320 3715929..3716612 - 684 WP_050155820.1 hemolysin III family protein -
BED35_RS18325 3716843..3717445 + 603 WP_069009466.1 HD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3714499..3715518 1019


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16425.21 Da        Isoelectric Point: 9.8217

>T65595 WP_005166047.1 NZ_CP016944:c3712797-3712372 [Yersinia enterocolitica]
VAQWRCDLRISWHTQLFSLLAHGVLVTLTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNIVLWKRH
EWVVIKQPWITRYGVLLSLQQTSSRSTRKRLWLAADSMSEEEWRQLCLLLRHSFGSDEGIN

Download         Length: 426 bp

>T65595 NZ_CP016944:c3712797-3712372 [Yersinia enterocolitica]
GTGGCCCAGTGGCGATGTGACCTGCGGATATCCTGGCACACTCAACTCTTCTCTCTATTAGCTCATGGCGTCCTGGTCAC
ATTAACGCTGGTTGCGCCTTGGCCTCAGGGCTATACCGCACTGTGGTTGGTGCTACTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAATATTACGTCTTGCCAAGGTGAGATCAGGCTGAAACCCGGCAATATAGTGCTATGGAAACGGCAT
GAGTGGGTCGTCATTAAGCAGCCGTGGATCACCCGTTATGGCGTATTATTGAGTTTACAACAGACAAGCAGTCGCTCAAC
CCGTAAGCGTTTATGGCTAGCGGCTGATAGCATGTCTGAAGAGGAATGGCGGCAATTGTGTCTCCTGCTGCGCCATTCAT
TTGGCTCCGATGAAGGTATTAATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10491.01 Da        Isoelectric Point: 5.1405

>AT65595 WP_004390965.1 NZ_CP016944:c3713044-3712778 [Yersinia enterocolitica]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KARGPVAM

Download         Length: 267 bp

>AT65595 NZ_CP016944:c3713044-3712778 [Yersinia enterocolitica]
ATGGAAATCGATAATAAAGCCCGTATTCACTGGGCGTGCCGTCGGGGTATGCGTGAACTGGATATCTCTATCATGCCGTT
TTTTGAACATGAATATGATGGCTTGAGCGATAACGAGAAACAGGTTTTTATCCGTTTGCTTGAGTGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCACGGGGAACCGCAGGATAGTGAGCTGCGTCAAATGGTCAAACTGATTCAAACACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FIQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FJE4

References