Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 3973068..3973603 Replicon chromosome
Accession NZ_CP016940
Organism Yersinia enterocolitica strain YE5

Toxin (Protein)


Gene name relE Uniprot ID A0A7U7G363
Locus tag BED32_RS18785 Protein ID WP_049528305.1
Coordinates 3973068..3973355 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U7FI63
Locus tag BED32_RS18790 Protein ID WP_005156229.1
Coordinates 3973352..3973603 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BED32_RS18755 3968328..3969134 + 807 WP_049528299.1 phosphonate C-P lyase system protein PhnK -
BED32_RS18760 3969148..3969882 + 735 WP_005156211.1 phosphonate C-P lyase system protein PhnL -
BED32_RS18765 3969879..3971027 + 1149 WP_005156213.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
BED32_RS18770 3971027..3971566 + 540 Protein_3601 ribose 1,5-bisphosphokinase -
BED32_RS18775 3971595..3972362 + 768 WP_069009520.1 phosphonate metabolism protein PhnP -
BED32_RS18780 3972363..3972992 - 630 WP_049529127.1 hypothetical protein -
BED32_RS18785 3973068..3973355 - 288 WP_049528305.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BED32_RS18790 3973352..3973603 - 252 WP_005156229.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BED32_RS18795 3973811..3974263 - 453 WP_005181269.1 YhbP family protein -
BED32_RS18800 3974337..3975503 - 1167 WP_069009524.1 alginate lyase family protein -
BED32_RS18805 3975517..3976632 - 1116 WP_005156237.1 ABC transporter ATP-binding protein -
BED32_RS18810 3976644..3977483 - 840 WP_005156238.1 carbohydrate ABC transporter permease -
BED32_RS18815 3977502..3978386 - 885 WP_005156239.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11016.10 Da        Isoelectric Point: 10.3544

>T65577 WP_049528305.1 NZ_CP016940:c3973355-3973068 [Yersinia enterocolitica]
MIYKLKFRSDALKEWGKIDKVIQQQFAKKLKKCCENPHIPSAKLRGLSDCYKIKLRASGFRLVYQVIEDCLVIAVVAVGK
RERSDVYNLASERLR

Download         Length: 288 bp

>T65577 NZ_CP016940:c3973355-3973068 [Yersinia enterocolitica]
ATGATTTATAAATTAAAATTTAGAAGTGATGCCCTAAAGGAATGGGGAAAGATAGACAAAGTTATTCAACAGCAGTTTGC
TAAAAAACTCAAAAAATGTTGTGAAAATCCTCATATTCCATCAGCAAAATTACGCGGATTATCAGACTGCTATAAAATAA
AATTACGGGCATCTGGTTTTAGGTTAGTTTATCAAGTTATTGAAGATTGTTTAGTTATCGCCGTGGTTGCCGTCGGCAAA
CGCGAACGCAGTGATGTTTATAACCTCGCCAGTGAACGGTTACGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9270.65 Da        Isoelectric Point: 4.2264

>AT65577 WP_005156229.1 NZ_CP016940:c3973603-3973352 [Yersinia enterocolitica]
MANIILSDTSASVSELKKNPMATVKAGAGYPVAILNRNQPAFYCIPAELYERMLDALDDQELIRLVTERESQPLIDVDLD
KYL

Download         Length: 252 bp

>AT65577 NZ_CP016940:c3973603-3973352 [Yersinia enterocolitica]
ATGGCTAACATAATTTTAAGTGATACGAGCGCAAGTGTCAGCGAGTTAAAGAAAAACCCTATGGCCACAGTCAAAGCGGG
GGCGGGCTATCCAGTGGCTATTTTGAATAGAAACCAACCGGCATTTTATTGTATCCCCGCAGAATTATACGAGAGAATGC
TAGATGCCCTTGATGATCAAGAGCTTATCAGATTAGTTACCGAACGAGAGAGTCAGCCACTCATTGATGTAGATCTGGAT
AAGTATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7G363

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FI63

References